Hi,all. As of today, I am suggesting a revised form of the Simplified Treatment Approach for lifting the partial methylation cycle block i ME/CFS. The revised form is shown below. The changes involve using liquid supplements where possible, and a capsule rather than a tablet, so that dosages can be divided more easily. Hopefully this will be more convenient than having to split tablets. I've eliminated folic acid from the protocol in favor of the active, reduced forms of folate, exclusively, since folic acid is not readily utilized by some patients, and it competes with the active forms for absorption. I've also provided for use of lecithin in place of phosphatidylserine complex, because the latter can decrease cortisol in patients whose cortisol is already too low. I would appreciate any feedback on how this works out for those of you who decide to try it. Best regards, Rich March 30. 2011 SIMPLIFIED TREATMENT APPROACH FOR LIFTING THE METHYLATION CYCLE BLOCK IN CHRONIC FATIGUE SYNDROME—March 30, 2011 Revision Rich Van Konynenburg. Ph.D. (Based on the full treatment program developed by Amy Yasko, Ph.D., N.D. which is used primarily in treating autism ) SUPPLEMENTS 1. General Vitamin Neurological Health Formula : Start with ¼ tablet and increase dosage as tolerated to 2 tablets daily 2. Hydroxy B12 Mega Drops : 2 drops under the tongue daily 3. MethylMate B : 3 drops under the tongue daily 4. Folinic acid : ¼ capsule daily 5. Phosphatidyl Serine Complex : 1 softgel capsule daily (or lecithin, see below) All these supplements can be obtained from (commercial website removed, not permitted). The fourth supplement comes in capsules that contain 800 mcg. It will be necessary to open the capsules, dump the powder onto a flat surface, and separate it into quarters using a knife to obtain the daily dose. The powder can be taken orally with water, with or without food. These supplements can make some patients sleepy, so in those cases they take them at bedtime. In general, they can be taken at any time of day, with or without food. Phosphatidyl serine can lower cortisol levels. Patients who already have lower than normal cortisol may wish to substitute lecithin  (at one softgel daily) for supplement number 5 above. Lecithin is also available from (removed) GO SLOWLY. As the methylation cycle block is lifted, toxins are released and processed by the body, and this can lead to an exacerbation of symptoms. IF THIS HAPPENS, try smaller doses, every other day. SLOWLY work up to the full dosages. Although this treatment approach consists only of nonprescription nutritional supplements, a few patients have reported adverse effects while on it. Therefore, it is necessary that patients be supervised by physicians while receiving this treatment.  Yasko, Amy, Autism, Pathways to Recovery, Neurological Research Institute, 2009, available from (removed).  General Vitamin Neurological Health Formula is formulated and supplied by Holistic Health Consultants LLC.  Hydroxy B12 Mega Drops is a liquid form of hydroxocobalamin (B12), supplied by Holistic Health Consultants. 2 drops is a dosage of 2,000 mcg.  MethylMate B is a liquid form of (6s)-methyltetrahydrofolate supplied by Holistic Health Consultants, based on Extrafolate S, a trademark of Gnosis S.P.A. 3 drops is a dosage of 210 mcg.  Folinic acid is 5-formyltetrahydrofolate. ¼ capsule is a dosage of 200 mcg.  Phosphatidyl Serine Complex is a product of Vitamin Discount Center. 1 softgel is a dosage of 500 mg.  Lecithin is a combination of phospholipids without phosphatidylserine. One softgel is a dosage of 1,200 mg.