LDN is used for reducing pain of certain types, mainly fibromyalgia aching. It works by partially blocking the opiate receptors. When these receptors are partially blocked (by the low dose) the number of receptors increases. After about two weeks the increased number of receptors outweighs the blocking (antagonising) "value" of the LDN. The result of this is reduced pain, as if you were taking morphine (or codeine compounds). LDN will not work the same day it is taken, that is a placebo effect. One of the best pain killing combinations is the following half aspirin + EPA 1 gram + DHA .5-1 gram. The aspirin potentiates the cox-2 enzyme inhibition. One of the effects of EPA. Again this anti-inflammatory, analgesic process takes at least one week to have effect. It is also helped by taking 5000iu vitamin D3 plus 400mg magnesium ( and preferably 1000mcg vitamin K2 mix) Aslo if taking vitamin D3 at the level of 5000iu daily or more (quite safe) you should also add 10,000iu vitamin A once every two days (or 5000iu daily). Zinc carnosine also seems to potentiate the effect. (Not sure why) As also stated anatabine is also an effective anti-inflammatory agent best taken along with Vitamin D3 and EPA. If your stomach can stand it curcumin via turmeric 95% also helps the same anti-inflammatory process.