by Mary Shomon It seems that there's isn't a newspaper, magazine or news program that hasn't recently featured a story on the amazing health benefits of soy food products and soy/isoflavone supplements. Soy is promoted as a healthy alternative to estrogen replacement for some women, as a possibly way to reduce the risk of breast cancer, as a way to minimize menopause symptoms, and as a healthier, low-fat protein alternative for meats and poultry. But what all the positive stories fail to mention is that there is a very real -- but very overlooked -- downside to the heavy or long-term use of soy products. Soy products increase the risk of thyroid disease. And this danger is particularly great for infants on soy formula. This is not information that the powerful and profitable U.S. soy industry wants you to know. The sale of soy products is big business, and the increasing demand for soy protein products, soy powders and soy isoflavone supplements is making that an even more profitable business than ever before. In researching my book, Living Well With Hypothyroidism, which covers the issue of soy products and the thyroid in great depth, I talked to Dr. Mike Fitzpatrick, an environmental scientist and phytoestrogen researcher who has conducted in-depth studies on soy, particularly the use of soy formulas. Dr. Fitzpatrick makes it clear that soy products can have a detrminental affect on both adults and infants. In particular, he firmly believe that soy formula manufacturers should remove the isoflavones -- that part of the soy products that act as anti-thyroid agents -- from their products. Researchers have identified that the isoflavones act as potent anti-thyroid agents, and are capable of suppressing thyroid function, and causing or worsening hypothyroidism. Soy is a phytoestrogen, and therefore acts in the body much like a hormone, so it's no surprise that it interacts with the delicate balance of the thyroid's hormonal systems. High consumption of soy products are also proven to cause goiter, (Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action, Divi RL; Chang HC; Doerge DR, National Center for Toxicological Research, Jefferson, AR 72079, USA, Biochem Pharmacol, 1997 Nov, 54:10, 1087-96) Note: The best source of information on soy and its negative impact on health can be found at the Soy Online Service, and in particular, its page on phytoestrogenic effects of soy, and impact on the thyroid. Isoflavones belong to the flavonoid or bioflavonoid family of chemicals, and are considered endocrine disruptors -- plants or other products that act as hormones, disrupting the endocrine system, and in some cases, this disruption involves acting as an anti-thyroid agent. (The grain millet, for example, contains high levels of flavonoids, and is commonly known as problematic for thyroid function). Flavonoids inhibit thyroid peroxidase (TPO), which disturbs proper thyroid function. The March 1999 issue of Natural Health magazine has a feature on soy that quotes Daniel R. Doerge, Ph.D., a researcher at the Food and Drug Aministration's National Center for Toxicological Research. Dr. Doerge has researched soy's anti-thyroid properties, and has said "...I see substantial risks from taking soy supplements or eating huge amounts of soyfoods for their putative disease preventive value. There is definitely potential for interaction with the thyroid." One UK study of premenopausal women gave 60 grams of soy protein per day for one month. This was found to disrupt the menstrual cycle, with the effects of the isoflavones continuing for a full three months after stopping the soy in the diet. Isoflavones are also known to modify fertility and change sex hormone status. Isoflavones have been shown to have serious health effects -- including infertility, thyroid disease or liver disease -- on a number of mammals. Dr. Fitzpatrick believes that people with hypothyroidism should avoid soy products, because, "any inhibition of TPO will clearly work against anyone trying to correct an hypothyroid state." In addition, he believes that the current promotion of soy as a health food will result in an increase in thyroid disorders. The Dangers of Soy Formulas Since the late 1950's, it has been known that soy formulas contain anti-thyroid agents. Infants on soy formula are particularly vulnerable to developing autoimmune thyroid disease when exposed to high exposure of isoflavones over time. ( Breast and soy-formula feedings in early infancy and the prevalence of autoimmune thyroid disease in children. Fort P; Moses N; Fasano M; Goldberg T; Lifshitz F Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030. J Am Coll Nutr, 1990 Apr, 9:2, 164-7) This study found that the frequency of feedings with soy-based milk formulas in early life was noticeably higher in children with autoimmune thyroid disease, and thyroid problems were almost triple in those soy formula-fed children compared to their siblings and healthy unrelated children. Dr. Fitzpatrick even believes that long-term feeding with soy formulas inhibits TPO to such an extent that long-term elevated TSH levels can also raise the risk of thyroid cancer. Not much is being done in the U.S. to make parents aware of the thyroid-related dangers of soy formulas, or to alert the public that heavy soy consumption may be a danger to thyroid function. Other countries, however, are far ahead of the U.S. In July of 1996, the British Department of Health issued a warning that the phytoestrogens found in soy-based infant formulas could adversely affect infant health. The warning was clear, indicating that soy formula should only be given to babies on the advice of a health professional. They advised that babies who cannot be breastfed or who have allergies to other formulas be given alternatives to soy-based formulas. Why more information is not available about these concerns is probably a function of the tremendous strength of the large agricultural companies that dominate America's soy market. One thing is clear, however. At the same time that health experts, and nearly every radio and television health program in the nation touts soy as the miracle health food of the new millenium, the United States pediatric and medical community needs to get more on top of this issue, and begin to counsel their patients regarding the serious impact use of soy products can have on thyroid function. How Much Soy is Safe? According to the Soy Online Service, for infants, any soy is too much. For adults, just 30 mg of soy isoflavones per day is the amount found to have a negative impact on thyroid function. This amount of soy isoflavones is found in just 5-8 ounces of soy milk, or 1.5 ounces of miso. For more information on how much soy is too much, see the Soy Online Service guidance page. The USDA has launched a website that is promoting the health benefits of use of soy and soy foods. The USDA site lists the isoflavone content of a total of 128 foods, including foods such as vegetarian hot dogs soybeans, chickpeas and tofu. This can help you in deciding how much soy to include in your diet. More information For more information on soy products, see: Soy Online Service Concerns Regarding Soybeans, from the Rheumatic Diseases website Are Soy Products Dangerous?, from the Gerson Healing Newsletter, Vol. 11, No. 5, Sep./Oct. 1997 Guide to Soy Isoflavones Soy to the World: A Guide to Incorporating Soy into Your Diet Sticking Out Our Necks and this website are © Copyright Mary Shomon, 1997-2003. All rights reserved. Mary Shomon, Editor/Webmaster All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. You should seek prompt medical care for any specific health issues and consult your physician or health practitioner before starting a new treatment program. 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