ssris's(prozac, paxil) antidepressants, causing autoimmune...

Discussion in 'Fibromyalgia Main Forum' started by pinkrainbow, Apr 2, 2006.

  1. pinkrainbow

    pinkrainbow New Member

    anyone aware of ssri antidepressant causing autoimmune illness? findings...
    pinkrainbow toronto, canada
  2. Bambi

    Bambi New Member

    do wish they would stop giving meds for the brain when they have NO proof that chemical embalances sp? even exist! Any time they start fooling with the brain chemicals you have to wonder what it will do.
  3. redtex

    redtex New Member

    book "prozac backlash". he is a harvard psychiatrist
  4. kalley167

    kalley167 New Member

    for several years and paxil before that. Wonder if it has anything to do with me having Lupus and FM/CFS now?
  5. goaska29

    goaska29 New Member

    I'm certainly not debating that this could be a possibility, but I did want to add that I never took a single anti-depressant until AFTER being ill for almost a year. Even then I only took one and it was for a couple months.

    Of course, this could mean nothing and there could still be a chance SSRIs cause autoimmune.

    Just thought I'd chime in ;)

  6. mom4three

    mom4three New Member

    Had not taken any medication prior to being ill.
  7. CarolK

    CarolK New Member

    I don't see the connection to autoimmune diseases. I started showing signs of FM even before ssri's were ever made! And from what I have read on posts by others on this board, they also had FM symptoms as far back as their childhood.

  8. cstraley3

    cstraley3 New Member

    I tried Zoloft and it triggered Lupus...The patient information sheets for Zoloft and Prozac indicate some people may show some change in their autoimmune system.
  9. Mikie

    Mikie Moderator

    Increase symptoms of a seizure state in some and bring on seizures in those predisposed to them. All the warning state that one should tell the doc if one has had seizures in the past. Thing is that we can have a chronic persistant low level seizure state and SSRI's, stimulants, and SNRI's can cause an increase in this seizure state. Some of the symptoms include RLS, sensory overload, insomnia, tinnitus, anxiety/panic attacks, and muscle spasms/tics.

    I will go get Dr. Cheney's article on SSRI's and stimulants. He dictates his articles so that he is a bit more dramatic than authors who write.

    Love, Mikie
  10. Mikie

    Mikie Moderator

    Paul Cheney, M.D., on SSRIs and Stimulants for Chronic Fatigue Syndrome: Frying the Brain?


    By Carol Sieverling
    Editor’s Note: This information is based on tapes of Carol Sieverling’s October 2000 patient visit with Dr. Cheney. He gave permission to share this information, but has not reviewed or edited it.

    Dr. Cheney recently came across some information regarding the dangers of Selective Serotonin Reuptake Inhibitors (SSRIs), such as Prozac, Zoloft and Paxil, and stimulants like Ritalin and Provigil. During office visits, Dr. Cheney shows patients the book Prozac Backlash: Overcoming the Dangers of Prozac, Zoloft, Paxil and Other Antidepressants by Joseph Glenmullen, M.D., a psychiatrist at Harvard Medical School. It includes endorsements from other Ivy League psychiatrists. Cheney calls the implications of this book "staggering."

    When talking with patients, Cheney usually opens the book to a picture of a monkey's brain before and after it received a very potent SSRI. The "before" photo shows a dark background filled with fine white lines and white blobs, healthy neurons. The "after" photo is very dark, only a few white lines and blobs remain. Most of the brain cells had been "fried."

    SSRIs and stimulants work by increasing the firing of neurons. While this often has great benefits in the short term, doctors are now realizing that long term use "fries" brain cells. The body views any neuron that fires excessively over time as damaged, and destroys it.

    SSRIs and stimulants, taken over a period of 10 years or so, can lead to a loss of brain cells, causing neurodegenerative disorders. Many doctors have recently seen a sudden increase in patients with neurological symptoms, and most have been on Prozac, or a similar drug, for about 10 years. Cheney is seeing this in his own practice.

    During office visits, Cheney also shows patients a copy of the May 22, 2000 issue of Newsweek with Michael J. Fox on the cover. It has an excellent article on Parkinson's Disease, a condition that involves a loss of neurons in the area associated with motor control. Parkinson's drugs stimulate the remaining neurons to "perform heroically," firing excessively. However, the article notes that while benefits are seen initially, neurological symptoms get much worse at the three to five-year point. Patients experience wild involuntary movements, etc. These drugs, though helpful in the short term, actually speed up the degenerative process.

    What mechanisms are at work causing neurons to be "fried?" SSRIs are often prescribed for depression, which involves a lack of serotonin. Serotonin is a neurotransmitter, a chemical messenger. One neuron releases a burst of it into the intersynaptic cleft, (the gap between neurons). The serotonin is then taken up by special receptors in the adjacent neuron. Thus a message is sent from one neuron to another, with serotonin carrying the message across the gap. Excess serotonin is cleared away before a new message is sent. A "reuptake channel" in one neuron vacuums up the left over serotonin.

    SSRIs are designed to address a lack of serotonin by blocking the reuptake channel from vacuuming up excess serotonin. While this allows more serotonin to connect with the receptors, often too much is left floating in the intersynaptic cleft. The only way the body can get rid of this excess serotonin is to oxidize it. Unfortunately, this turns it into a toxic compound that, over time, kills both the sending and receiving neurons.

    Cheney stated, "What starts out as an attempt to increase serotonin and reduce symptoms ends up with the destruction of the serotonergic system itself. It takes about a decade, more in some, less in others.

    Now when the serotonergic nerves are dead, you start getting these motor neuron problems, which is what we're seeing." Cheney commented, "You know what a lot of doctors (who do not understand CFIDS) are doing? They're saying 'Well, let's just give them an antidepressant'. And they are frying their (patients') brains and they don't even know it. In fact, a CFIDS patient on one of these drugs fries their brain even faster than a non-CFIDS person." (See the article on Klonopin for an explanation.)

    Cheney went on to say, "The other way some people with CFIDS are going is stimulating the brain, using drugs like Ritalin or Provigil. They do the same thing - they fry the brain. They cause neurons to fire at lower stimulus by lowering the firing threshold. All stimulants are dangerous, especially over the long haul. I'm not saying that you might not find them useful in the short-term. But over the long term, the physiology demands that neurons that fire excessively be killed."

    Cheney strongly urges anyone taking antidepressants or stimulants to read Glenmullen's book, which lists safe alternatives to SSRIs.

    © 2002 Carol Sieverling. Reprinted with permission.

    Related Cheney Article:
    Dr. Paul Cheney Discusses the Benefits of Klonopin

  11. pinkrainbow

    pinkrainbow New Member

    Goaska99, and EVERYONE!..HUGS AND LOVE RIGHT BACK AT you!!!(sorry for screaming!)

    Wow:!!! many reactions, from yes i agree, or yes it makes sense, and makes me mad, or no, don't agree, or i didn't take it long enough, or didn't take it till after i got the illness..
    Isn't it wonderful that there are ???many members, with what 50 posts a day, from ?how mant countries, i assume probably u.s., mostly, then canada and england?..i would love to know where we are all from, and so glad i have friends that unfortunately have shared a similar path is mine!
    Yes this news is very upsetting if it is all true, and Dr. Chenney a well-known cfids specialist, sure seems to think ssri's a problematic, especially after a decade...and i thought my insanity was simply menopause, meds, cfids, fm, thyroid and addison's!!!..could be prozac..could even be prozac perhaps combined with a virus i picked up while travelling, coupled with stress, activated this whole nightmare, that i no longer believe i will wake up from!!!>>NOW I HAVE been sick almost as long as i worked!..I remember the first cfids meeting i went to, at the time, thinking the specialist had said take 3 months off work..only to find a woman there who had it 22 years..and half the people there didn't have insurance!..ouch!
    17 years later, seems it was accurate..thankfully it isn't considered "all in your head" anymore,...but perhaps with prozac it may have started there..
    I don't believe was the only causative factor, but i think it probably helped excell and perhaps increase the severity of it..!
    Course woman were on premarin(estrogen from pregnant horse's urine) for about 20 years too, before they figured out it causes ca of the breast, strokes, etc...

    I think, that living in the solution is better than focusing on the problem, but that attitude the last 5 years, after the 20 dr's, and 9 naturopaths,etc...that finally had me 'give up', in the sense, i didn't want any more 30 tubes of blood, and stool and urine samples constantly checked for candida, parasitese and fungus, etc., i was all dr'ed out!..but knowledge is power, and i hope to make a nice little home here with all you wonderful people, bumbling with knowledge, a place to exchange ideas, solutions, thoughts, good and bad days, and help each other physically, emotionally and spiritually, to grow, no longer feel alone like i have(our cfids group folded after about 5 years, everyone was too sick to carry on), whereas the fm group survived, as the people in the group, looked and acted very differently..more if your interested.
    Too many posts to respond to individually, as i also recovering from pneumonia, and an abscessed tooth, root canal, and toxic parents visits, along with intense stress from my new diagnosis with addison's, and how long i might be here!
    so thanks so much for the warm welcome, and i certainly don't have the answers, but merely wanted to pass on what i had read, to see if other's thought there was validity to it..and whoever posted dr. chenney's article, and mentioned a book by someone else..? i think is was prozac burnout?...was helpful in putting the light on things.
    so how many from Canada! AYE?
    love and hugs..
    p.s.- is this a ng like yahoo, where we can put each other's photo's in?...
  12. pinkrainbow

    pinkrainbow New Member

    although i know that there can be an inbalance in brain chemicals, a reason many shrinks can use to help a depressed patient to take antidepressants,i think with severe illness, and loss, antidepressants are often prescribed to help to deal with the grieving process that happens when you get such a severe illness, that you loose your job, perhaps husband/boyfriend, friends in general, all the roles that helped define who you were, before your identity can seemingly be "that of an illness"!..that's why i took them, and still do..but i have a few things to discuss with my shrink this month!

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