I did a search on titles to read up on past posts about Topamax. I notice most of you were/are taking it for migraines, which I am not prone to (thank you, Lord). I am hoping it will help my fibro symptoms. My doctor says I will be his guinea pig in this respect. My pharmacist gave me the dire warnings I had already read about before requesting the drug from my doctor. I am desperate for some relief from this daily agony and am willing to take some risks at this point. The first week has gone well. I've only taken 25 mg each night. Tomorrow morning I add 25 mg each morning for a week and titrate up each week to 100 mg. I was a bit sleepy for the first days but my head was clear and focused and I felt calm. I usually have severe fibro fog. That seems to be gone. Also I didn't have the usual twitches and jerks (just two quick ones a few days ago). The backs of my thighs burn fiercely when I sit so I have to go. That's one of the main things I'm hoping that the Topomax will help with. Will keep you posted. Hoping to hear from anyone else who has not shared his/her experience with Topamax yet.