Streptococcal Syndrome / Polymyalgia Rheumatica

Discussion in 'Fibromyalgia and ME & Chronic Fatigue Syndrome' started by RadioFM, Jun 23, 2014.

  1. RadioFM

    RadioFM Active Member

    Radio: We have had problems with streptococcal infections in my family for many years. My sister develop Meningitis at 5 years old. My brother develop Myocarditis at 25 and my grandmother Rheumatic fever at age 19. I feel that streptococcal infections may need more research. Please review these links below.


    "Staphylococcus aureus is a bacterial species which commonly infects the human body where its growth and persistence is limited by the amount of iron present (Massey, 2001). Up to 25% of ndividuals have S. aureus colonies either in their nose or on their skin (CDC, 2006). S. aureus is known to cause a multitude of illnesses in infected humans, most notably Cellulitis, Osteomyelitis, Endocarditis, Toxic Shock Syndrome, and Bacteremia.S. aureususually coinfects with another bacterial species,Pseudomonas aeruginosa (Mitchell, 2010)" See more here: http://www.uta.edu/math/preprint/rep2013_05.pdf



    "Post streptococcal syndromes may manifest in multiple organs including the musculoskeletal, central nervous, urinary, integumentary, and circulatory systems. The commonly described post streptococcal syndromes include acute rheumatic fever, post streptococcal glomerulonephritis, post streptococcal arthritis, and pediatric autoimmune neuropsychiatric disorders. Classically, these complications occur more often in children. While much is written in the pediatric literature regarding these syndromes, a compilation of information is difficult to find. This article summarizes some of the frequently described post streptococcal syndromes and associations." See more here: http://ispub.com/IJRH/6/2/12159






    "Post streptococcal related myalgia/myositis
    : Myalgias are reported in association with streptococcal and/or post streptococcal syndromes. Clinical presentations include severe muscle pain and/or tenderness.37,38 Laboratory data may show elevation in sedimentation rates and leukocytosis, but muscle enzymes and muscle biopsies may be normal. Several cases of post streptococcal polymyalgias have responded to penicillin, NSAIDs or steroid therapy.38-40 " See more here:http://ispub.com/IJRH/6/2/12159




    Polymyalgia Rheumatica - CRASH! USMLE Step 2 and 3


    Last edited: Nov 13, 2014
  2. Mikie

    Mikie Moderator

    No one knows for sure the cause of our conditions. Many are convinced that whatever triggered their CFIDS/ME or FMS is the cause, but cause is not the same as relationship. It's a common assumption people make. I do not believe we can heal until we address our chronic infections but even after or infections are under control, most of us are not cured. Physical or emotional trauma, stress, injury, etc. are known to trigger our conditions. There can be many triggers.

    Love, Mikie
  3. RadioFM

    RadioFM Active Member

    Last edited: Nov 18, 2014
  4. Mikie

    Mikie Moderator

    Some bacteria do not go away. People with Lyme or mycoplasma infections may have the bacteria go into a cyst form deep inside body tissue. Getting injured, sick or being stressed can allow these latent cysts to become active again. I have a chronic mycoplasma infection which has been latent for a long time (knocking on wood :) Unfortunately, many docs do not realize that just a couple of courses of ABX will not stop these infections. It takes at least a six-month course of ABX to deal with mycoplasma infections and, even then, one may have to pulse off and on the ABX for a much longer time. I was on Doxycycline for 2 1/2 years to drive my mycoplasma infection into latency. That's likely because it went untreated for so long until I found Dr. Nicolson.

    Herpes-Family viral infections also never go away and can reactivate under the same conditions as above. Keeping everything latent may be the best we can do with some of these chronic infections. Building up a healthy immune system is absolutely necessary to keeping these infections at bay. Our treatments have to be multi-faceted. Transfer Factors can really help with this. I also took them and they were much stronger than either ABX or AVs.

    Love, Mikie
    RadioFM likes this.
  5. RadioFM

    RadioFM Active Member




    Radio:
    Lyme disease is a hug factor to consider and needs to be evaluated.


    Last edited: Nov 12, 2014
  6. Abdulrahman

    Abdulrahman Member

    Hello Radio,

    I am responding to your first message. Wth regard to those that have repeated and long term bacterial infections as you stated such as Myocarditis [ Heart Tissue Infection] and Menigitis there is an important factor i discovered; and that is that the immune deficiency is not the only cause of such infections. A very important cause is the serious deficiency in human tissues of critical minerals that are anti-viral and anti-bacterial.

    The following minerals exhibit anti-bacterial resitance when incorporated in tissues such as heart tissue, Kidney tissue, Liver, Brain....: Copper, Selenium, Iodine

    For those with a deficiency in the body of the above minerals, there will be a low resistance to bacterial attack, and this is dangerous to the critical organs. The proof of the above statement is that if you study the concentration of the above minerals in Heart Tissue, Liver, and Kidneys the levels are far higher than found in other tissues. The body is incorporating a high concentration of these minerals in such critical organs to act as an anti-viral and anti-bacterial shield.

    The majority of people have little idea of how much Copper or Selenium should be stored in the body and where are the highest food sources.
    RadioFM likes this.
  7. Abdulrahman

    Abdulrahman Member

    ANTIBACTERIAL EFFECT OF SELENIUM, GERMANIUM, AND LITHIUM ON CLINICALLY IMPORTANT BACTERIA GROWING IN PLANKTONIC CULTURE AND BIOFILMS – SOME MEDICAL IMPLICATIONS
    Alquthami, Khalid (2012)ANTIBACTERIAL EFFECT OF SELENIUM, GERMANIUM, AND LITHIUM ON CLINICALLY IMPORTANT BACTERIA GROWING IN PLANKTONIC CULTURE AND BIOFILMS – SOME MEDICAL IMPLICATIONS. PhD thesis, University of Sheffield
    Abstract
    The antibacterial effects of lithium, selenium, and germanium were evaluated with respect to growth, biofilm formation, and mutational frequencies (MF), of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Selenium showed the highest antimicrobial and bactericidal activities as shown by zone of inhibition assay and scanning electron microscopy imaging (SEM). The SEM images showed that the metals in culture media led to cell disintegration that could have resulted in the leakage of cytoplasmic constituents, and cell dehydration. In biofilms, the combination of metal and antibiotics increased oxidative stress, mutational frequencies(MF), and formation of mutator phenotypes. Adding the antioxidant ascorbic acid reduced the S. aureus biofilm MF, but increased the MF of P. aeruginosa biofilm. Image analysis showed that metal and ascorbic acid cooperated in destroying cell structure pointing to the effectiveness of the antioxidant to prevent the formation of reactive oxygen species, oxidative stress, and bacterial DNA mutation rates. Generally, results showed that the antibacterial effect depended on the combinations of metal, antibiotic and antioxidant different and the bacterial strain being tested. Biofilm cultures yielded adherent colony variants that differed in appearance and in the capability of the variants to form hypermutator phenotypes with relatively high MFs. There was perfect sequence alignment of an approximately 500 bases of the P. aeruginosa 16S rDNA fragment of the wild-type and colony variants. In contrast, the 16S rDNA sequence of S. aureus variant showed several mutations, deletions, and insertions, implying the high mutability of S. aureus when exposed to external factors. Further studies should be conducted on the molecular basis of the antibacterial action and possible applications of selenium, germanium, and lithium in reducing antibiotic resistance, and biofilm infection. In addition, there is a need to understand bacterial adaptation to metals and their interaction with other antimicrobial agents in order to design effective drug therapies.
    RadioFM likes this.
  8. Abdulrahman

    Abdulrahman Member

    http://en.wikipedia.org/wiki/Antimicrobial_properties_of_copper


    Mechanisms of antibacterial action of copper[edit]
    In 1973, researchers at Battelle Columbus Laboratories[4] conducted a comprehensive literature, technology and patent search that traced the history of understanding the “bacteriostatic and sanitizing properties of copper and copper alloy surfaces” which demonstrated that copper, in very small quantities, has the power to control a wide range of molds, fungi, algae and harmful microbes. Of the 312 citations mentioned in the review across the time period 1892–1973, the observations below are noteworthy:
    A subsequent paper [11] probed some of copper’s antimicrobial mechanisms and cited no fewer than 120 investigations into the efficacy of copper’s action on microbes. The authors noted that the antimicrobial mechanisms are very complex and take place in many ways, both inside cells and in the interstitial spaces between cells.
    Examples of some of the molecular mechanisms noted by various researchers include the following:
    • The 3-dimensional structure of proteins can be altered by copper, so that the proteins can no longer perform their normal functions. The result is inactivation of bacteria or viruses [11]
    • Copper complexes form radicals that inactivate viruses.[12][13]
    • Copper may disrupt enzyme structures, and functions by binding to sulfur- or carboxylate-containing groups and amino groups of proteins.[14]
    • Copper may interfere with other essential elements, such as zinc and iron.
    • Copper facilitates deleterious activity in superoxide radicals. Repeated redox reactions on site-specific macromolecules generate OH- radicals, thereby causing “multiple hit damage” at target sites.[15][16]
    • Copper can interact with lipids, causing their peroxidation and opening holes in the cell membranes, thereby compromising the integrity of cells.[17] This can cause leakage of essential solutes, which in turn, can have a desiccating effect.
    • Copper damages the respiratory chain in Escherichia coli cells.[18] and is associated with impaired cellular metabolism.[19]
    • Faster corrosion correlates with faster inactivation of microorganisms. This may be due to increased availability of cupric ion, Cu2+, which is believed to be responsible for the antimicrobial action.[20]
    • In inactivation experiments on the flu strain, H1N1, which is nearly identical to the H5N1 avian strain and the 2009 H1N1 (swine flu) strain, researchers hypothesized that copper’s antimicrobial action probably attacks the overall structure of the virus and therefore has a broad-spectrum effect.[21]
    • Microbes require copper-containing enzymes to drive certain vital chemical reactions. Excess copper, however, can affect proteins and enzymes in microbes, thereby inhibiting their activities. Researchers believe that excess copper has the potential to disrupt cell function both inside cells and in the interstitial spaces between cells, probably acting on the cells’ outer envelope.[22]
    RadioFM likes this.
  9. Abdulrahman

    Abdulrahman Member

    Warning: Please note that the above minerals should be taken only in their organic state otherwise when in their mineral chemical form, they are looked upon by the body as pollutants, not as critical minerals to be used for physiological functions. Therfeore, mineral Copper is damaging to your health, and the same applies to Selenium.

    But when eaten through high concentration organic sources, the result is instant absorption by the body and very great health benefits. Plants absorb the minerals from soils and then transform the minerals into organic molecules which the human body will absorb well. In addition, animals eat such plants and will concentrate the minerals in some organs. For example, liver is the highest source of copper in animals and humans because it is stored there by the animal body. The Highest plant sources in the world for the anti-bacterial and anti-viral minerals are:

    Copper: Tamarind Fruit ----------------- 20 mg Copper/100 g Fruit , Extremely High Concentration, about 100 x typical concentrations in foods

    Selenium: Brazil Nuts -------------------- 550 mcg/Ounce or six to eight nuts, Extremely High about 20 x other highest selenium foods

    Sulfur: Mustard Seed or Mustard Sauce -------------- 10,000 mg Sulfur/100 g seed extremely High, about 20 x other high Sulfur Foods

    Iodine: Seaweed -------------------Varies from seaplant to seaplant but can be averaged at 1000 mcg Iodine/1 grams dried seaweed


    Abdulrahman
    RadioFM likes this.
  10. RadioFM

    RadioFM Active Member

    Radio: The question I am now asking is there a connected to Polymyalgia Rheumaticain in subgroups of misdiagnosed Fibromyalgia and Lyme disease?



    Polymyalgia Rheumatica -

    "Polymyalgia rheumatica is an inflammatory syndrome that is characterized by pain and stiffness of the neck, shoulders, lower back, and hips. It is often accompanied by constitutional symptoms such as fever, weight loss, and feelings of uneasiness or discomfort. Individuals who have the syndrome complain of pain and stiffness severe enough to make routine tasks such as combing their hair or getting dressed quite difficult."

    "Inflammation of the bursa (bursitis), synovial membrane (synovitis), and tendon sheath (tenosynovitis) of the hip and shoulder are characteristic of polymyalgia rheumatica. The etiology is unknown, but the syndrome is believed to have an autoimmune component and does not appear to stem from any defect of muscle or joints. One explanation is that infection may trigger an exaggerated immune response, which in turn affects individuals with an inherited predisposition for developing the condition. About 15% of people diagnosed with polymyalgia develop temporal arteritis, also called giant cell arteritis (GCA); correspondingly, 50% of people with GCA also develop polymyalgia (Saad). Polymyalgia and temporal arteritis share several characteristics: they are positive for the human leukocyte antigen HLA-DR4, demonstrate systemic monocyte activation, and show a polymorphism in the region of the HLA-DRB1 gene, suggesting a genetic component."



    Radio: Our genetic predispositions may determine your risk factor. Here is a good article on the HLA-DR:



    Last edited: Nov 20, 2014 at 8:08 PM
  11. jepps

    jepps Member

    Also interesting is this research:
    http://www.ncbi.nlm.nih.gov/pubmed/24566629

    It´s the fix relationship between streps and candida, which makes both pathogene. To treat successfully the chronic strep infection, we must address both candida and streps as well as the biofilms.
    RadioFM likes this.
  12. RadioFM

    RadioFM Active Member

  13. RadioFM

    RadioFM Active Member

  14. RadioFM

    RadioFM Active Member

  15. RadioFM

    RadioFM Active Member