Hi, my name is Rachel and although I have been sick with CFIDS/FMS for about 13-15 years I am new to support sites like this one. I live in California and spent most of last year commuting to Michigan to see Dr. Lerner. I have been on 3 doses of Valcyte a day since June 2010. (after having to stop for a short time because the nausea was so bad). I am also taking 4 doses of Valtrex a day. Lerner made a point to say that 4th dose is important as well as NOT taking the generic. I had to stop going to Lerner at the end of the year due to all the costs except the meds being out of pocket and I didn't think I could do one more plane trip. I finally found a doctor who agreed to follow Dr. Lerner's protocol, he had treated me for Lyme previously. Unfortunately, he really doesn't "get" the treatment just willing to help me try it, so I can't ask questions. So, finding a place I can talk about this is really great. I have been on Valcyte for 9 months and Valtrex awhile shorter. I have been very sick (on top of regular sick) for the last 2 months and don't know if it is related to the protocol because I had some times in between the Herx response and when I started feeling this horrible where things were ok. I am relieved to read other people had emotional responses because I have also had anxiety and depression(this past 2 months) and didn't know if that was due to being so isolated and feeling so miserable or if it was connected in a different way. When I first started this it was the first time I had HOPE and for that was willing to go through just about anything. Now, am losing hope and don't know what to do. I have read about people being on AV's for a relatively short time with improvement and someone who has been doing it for 27 months. I know Lerner's last study had people on the protocol for 2 1/2 years. I guess what I would like to know is if I should keep on it and suffer through until I feel better or stop and see if things improve. The local doc will only test for CMV, HHV-6, EBV, etc.. every 3 months. He did agree to testing my kidney/liver once a month when I pushed. Since he is only prescribing this because I wanted to asking him will only bring a its up to you answer. Has anyone else become pretty much bed bound this far in to treatment. Before I started I had the usual up & downs. Now just flat out down. Very Sorry this is so long, but I feel desperate and need some direction. Thank You.