STUDY: 8% genetic material FROM viruses -causing problems-?

Discussion in 'Fibromyalgia Main Forum' started by victoria, Jan 14, 2010.

  1. victoria

    victoria New Member

    SO 'things' get more and more complicated as new research comes out. I wouldn't doubt there are others that would affect our immune systems, for one.

    Most interesting is the statement,

    "Until now, retroviruses were the only viruses known to generate such endogenous copies in vertebrates. But Feschotte said that scientists have found that non-retroviral viruses called bornaviruses have been endogenized repeatedly in mammals throughout evolution."

    Human genome carries 40 million-year-old virus
    http://www.tgdaily.com/general-sciences/45412-human-genome-carries-40-million-year-old-virus
    Emma Woollacott | Fri 8th Jan 2010,

    About eight percent of human genetic material comes from a virus and not from our ancestors - and could be causing mutations and psychiatric disorders such as schizophrenia.

    Research from the University of Texas shows that the genomes of humans and other mammals contain DNA derived from the insertion of bornaviruses, RNA viruses whose replication and transcription takes place in the nucleus.

    The assimilation of viral sequences into the host genome is a process referred to as endogenization. It occurs when viral DNA integrates into a chromosome of reproductive cells and is subsequently passed from parent to offspring.

    Until now, retroviruses were the only viruses known to generate such endogenous copies in vertebrates. But Feschotte said that scientists have found that non-retroviral viruses called bornaviruses have been endogenized repeatedly in mammals throughout evolution.

    Bornaviruses are unique because they infect only neurons, establishing a persistent infection in their host's brain, and their entire life cycle takes place in the nucleus of the infected cells.

    Feschotte said this intimate association of BDV with the cell nucleus prompted researchers to investigate whether bornaviruses may have left behind a record of past infection in the form of endogenous elements. They searched the 234 known eukaryotic genomes for sequences similar to that of BDV.

    "The researchers unearthed a plethora of endogenous Borna-like N (EBLN) elements in many diverse mammals, " Feschotte said.

    The scientists were also able to recover spontaneous BDV insertions in the chromosomes of human cultured cells persistently infected by BVD. Based on these data, Feschotte proposes that BDV insertions could be a source of mutations in the brain cells of infected individuals.

    "These data yield a testable hypothesis for the alleged, but still controversial, causative association of BDV infection with schizophrenia and mood disorders," Feschotte said.

    Feschotte's research appears in Nature.

  2. AuntTammie

    AuntTammie New Member

    looks interesting.....and a bit depressing.....it's not like we don't already have enough wrong with us, after all, and though this is not about CFS, it certainly stand to reason that there could be other forms of this type of virus that could be associated with it......but OTOH more knowledge can only help
  3. spacee

    spacee Member

    Yes, Dr. Cheney and Dr. Klimas both believe this...Those are the only two I have seen/heard state it.

    I think that is why Cheney stopped looking for "the" virus and went another ways. Individual treatment.

    It is going to be interesting to see if Kilmas sets her new office up and follows some of Cheney's doings.

    Spacee