Study: cytokines and FM

Discussion in 'Fibromyalgia Main Forum' started by tansy, Dec 11, 2008.

  1. tansy

    tansy New Member

    Plasma Cytokine Fluctuations Over Time in Healthy Controls and
    Patients with Fibromyalgia.

    Exp Biol Med (Maywood). 2008 Dec 8. [Epub ahead of print]

    Togo F, Natelson BH, Adler GH, Ottenweller JE, Goldenberg DL, Struzik
    ZR, Yamamoto Y.

    Department of Work Stress Control; Japan National Institute of
    Occupational Safety and Health.

    PMID: 19064941

    We examined the pattern of cytokine secretion across the 24 hr day
    for women with widespread pain and tenderness having the diagnosis of
    fibromyalgia (FM) and matched healthy controls.

    Subjects were given time to habituate to being in a clinical research
    laboratory environment and then were sampled for cytokines without
    their being disturbed for a 24 hr period including an 8 hr sleep period.

    Cytokine levels were uniformly low but characterized by bursts of
    secretion. Bursting occurred either in singlets or in doublets with a
    range from 88 to 131 min between doublets. There was an element of
    synchronization of these bursts with most occurring at the beginning
    of sampling. FM patients showed a shift to increased IL-10 in the
    night-time compared to controls. The relation between this
    anti-inflammatory cytokine to the pro-inflammatory cytokines studied
    also differed between groups: FM patients showed a reduced ratio of
    IL-10 burst amplitude to that of pro-inflammatory cytokines IL-1beta,
    IL-8, and TNF-alpha.

    We interpret this to indicate a skew away from the normal balance
    favoring pro-inflammatory cytokines in controls toward one favoring
    an anti-inflammatory response in FM. These changes toward
    anti-inflammatory predominance in FM may explain their common
    complaint of disturbed sleep because these cytokines are known to
    disrupt sleep.