From the Co cure Archives. Note: Resveratrol more effective than CBT in increasing activity in mice with CFS. More seriously, an animal model is a key step in developing a model of a disease. The pros are mice are inexpensive to use and unlike humans can be sacrificed to study internal organs and damage. The drawbacks are they are not humans so extrapolation to humans cannot always be made. Biol Pharm Bull. 2011;34(3):354-9. Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells. Moriya J, Chen R, Yamakawa J, Sasaki K, Ishigaki Y, Takahashi T. Department of General Medicine, Kanazawa Medical University. Abstract Neuroimaging evidence showed structural and/or functional abnormalities existing in the central nervous system, especially the hippocampus, in chronic fatigue syndrome (CFS) patients. However, its pathophysiologic mechanisms are unclear in part due to the lack of an applicable animal model. We established a chronic fatigue murine model by six repeated injections of Brucella abortus antigen to mice, which was manifested as reduced daily running activity and hippocampal atrophy. Thereafter, resveratrol, a polyphenolic activator of sirtuin 1, was used for treatment in this model. Daily running activity was increased by more than 20%, and the hippocampus was enlarged after 4-week resveratrol therapy. Furthermore, resveratrol inhibited neuronal apoptosis and expression of hippocampal acetylated p53 in the fatigue mice. Resveratrol also improved neurogenesis and expression of brain-derived neurotrophic factor mRNA in the hippocamous. We concluded that repeated injection of B. abortus antigen could induce hypoactivity and hippocampal atrophy in mice. Resveratrol may be effective for improving fatigue symptoms and enlarging the atrophic hippocampus by repressing apoptosis and promoting neurogenesis.