I have CFS, and have been diagnosed with adrenal insufficiency. Its low enough that I need cortisol. I tried taking cortef (hydrocortisone) and I didnt get any better. I have hepatitis C, herpes and who knows what other infections, and was in a bad flare anyway, so i dont know if it made me worse or just didnt have any effect. I went off it, and have been doign IV vitamin C. Now I am feeling a little better, but totally exhausted. The medication says its contraindicated in patients with hepatitis or other viral, fungal infections. But then I have also read that people on cortef may need to raise their dose if they get sick. i am really confused. i go to the doctor on thursday, and he will probably want me to try the cortef again, but I am afraid because of the hepatitis. Does anyone know anything else I can take besides cortef?