I posted a topic of being really depressed. I have been down but never so down that I could not function. Here are my meds Synthroid Ritalyn - to offset opiod drowsiness combipatch - estrogen Cymbalta Elavil Klonipin Methadone Dilaudid Elmiron I take a multi vitamin, Fish oil, and B-12 shots monthly. I have been on Elavil for over 20years. The other meds I have been on at least 10 years. Elmiron is for interstitial cycstitis. I am making an appt with a Psychyatrist today. I feel my gp has done all he can do. If anyone knows of anything that might help, I would appreciate the information. Thanks, and painfree to all.