I just finished an appointment with my psychiatrist. I have been wanting to discontinue Effexor because of the withdrawal problems, and I was fully intending to just start to withdraw totally...but slowly...from antidepressants. However,I believe that Effexor is no longer working for me, and the symptom of depression and the pain of FM has been so bad for the last month or so, that I had looked into Cymbalta. The doctor agreed that I should change to Cymbalta. If I get stabilized, then he said that getting off Cymbalta is easier than the Effexor. So, he has given me a 7 week schedule, and bless his heart, the medications to make the switch. Wonderful. I will keep you posted. I am hoping the process will not be as bad as I will be taking another medication that works on the same neurotransmitters. Ain't life fun? (-: Sue If any of you have done this, what was your experience?