Do CFS sufferers typically have swollen lymph nodes? I was diagnosed with POTS, a dsyautonomia that is supposed to be very similar to CFS, but my doctor and I are having doubts. I had a CT scan of a chain of swollen lymph nodes in my neck, which have been present since I've been sick for over a year now, and the ENT said that they are definitely swollen and perhaps I should look into something like Chronic Fatigue Syndrome. I have read up on CFS, but haven't read anything about lymph nodes actually being swollen. Have read that they can feel tender and painful, but nothing about them being enlarged. My lymph nodes have had the same maximum size, but they fluctuate from feeling almost nonexistant to their max size, never larger though.