I started taking Cymbalta not too long ago. I had been taking my tramadol with it all along. My doc knows, so I figured it must be safe. Then I started having some very extreme sensations as if my nervous system was on fire. After some investigation. WEBMd does NOT recommend taking these two drug together as it can lead to serious or even deadly seratonin symdome! Thought that you all might need the info....plus what can I take besides Cymbalta that won't make me feel like a total zombie?