Over the last 2 weeks I've had to come off the effexor completely, rather more rapidly than desirable due to the toxic/allergic(?) responses outlined in my earlier post. Now it's been 5 days without any effexor and I seem to be settling down after a period of rebound or withdrawal syndrome (quite a euphamism isn't it). Interesting thus far I feel better both physically and emotionally without any medication; time will tell of course but I feel much more like myself ...after I stopped my 2 days of "spendy" behaviour and stopped being irritated by the neighbour's barking dog. Thanks again for the suggestions which I did follow up on and cross your pinkies for me. Catherine. p.s. Tansy, I read a recent post of yours in which you described profound muscular fatigue without CNS fatigue. I have that as well and I'm wondering what you put it down to, and how you approach treating the problem. The only thing that works for me is to rest my muscles absolutely; cane use, no carrying of anything. Very demoralizing. Anyway, do you have any other recuperative or preventative suggestions you can share? Thanks.