I have had CFS for 20 years and controlled it for 16 years with LEM, and for the last 4 with AHCC. Apparently the AHCC has stopped working because I have been in relapse a month. It was suggested to me by immunesupport.com that I should go off of the AHCC for a month, then it will work again. That did happen to me with LEM and going off if a month did the job! They also suggested I take Transfer Factor Essentials during that month to prevent a complete relapse. After reading your posts on TF, I find that I can HERX and actually get worse at first on TF! Presently I am taking one every other day and on those days I do have a mild headache. I am still slowly getting off of the AHCC. My question is, if I continue to take the TF one every other day and stay at that level, will it still in time kill the pathogens as effectively as if I took 2/day? If going slowly will do the same job I'd like to go that route. I have some major obligations this month that I just can not get totally sick for. Thanks so much!