I think protease is more involved in ME and FM, but I will be presenting evidence of a lack of DNase1 also. For instance, the low levels of uric acid that that have been found in ME would point directly to DNase1. Uric acid is the final break down product of dietary DNA. If you lacked DNase1 (which digests dietary DNA) you would have lower levels of uric acid. Uric acid is a potent scavenger of peroxynitrite ( a powerful oxidant).