Radio: I have had problems with streptococcal infections in my family for many years. My sister develop meningitis at 5 years old. My brother develop myocarditis at 25 and my grandmother rheumatic fever at age 19. Streptococcal syndromes and related co-infections could be the missing factor being misdiagnoses as fibromyalgia. I feel this could be the answers we have been looking for many subgroups. Please review these links below. Streptococcal syndromes / "Spondyloarthropathies" / Polyomyositis / Polymyalgia Connection? "Post streptococcal syndromes may manifest in multiple organs including the musculoskeletal, central nervous, urinary, integumentary, and circulatory systems. The commonly described post streptococcal syndromes include acute rheumatic fever, post streptococcal glomerulonephritis, post streptococcal arthritis, and pediatric autoimmune neuropsychiatric disorders. Classically, these complications occur more often in children. While much is written in the pediatric literature regarding these syndromes, a compilation of information is difficult to find. This article summarizes some of the frequently described post streptococcal syndromes and associations." See more here: http://ispub.com/IJRH/6/2/12159 Post Streptococcal Syndromes, A Rheumatologist Perspective Evaluation of Post streptococcal Illness - American Family ... Post-Stretococcus Reactive Arthritis – Poorly Diagnosed ... Post Streptococcal Myalgia: An Under-recognized Acute poststreptococcal polymyalgia? "Post streptococcal related myalgia/myositis: Myalgias are reported in association with streptococcal and/or post streptococcal syndromes. Clinical presentations include severe muscle pain and/or tenderness.37,38 Laboratory data may show elevation in sedimentation rates and leukocytosis, but muscle enzymes and muscle biopsies may be normal. Several cases of post streptococcal polymyalgias have responded to penicillin, NSAIDs or steroid therapy.38-40 " See more here:http://ispub.com/IJRH/6/2/12159 Bacterial, Fungal, Parasitic, and Viral Myositis Exploring necrotizing autoimmune myopathies with a novel <---Key Test Polyomyositis Polymyositis | Better Health Channel Post-streptococcal reactive myalgia - Rheumatology Beta haemolytic streptococci and musculoskeletal sepsis Radio: Dysbiosis toxins and other chronic infections can be another possible contributing factor. Such as: Enterococcus, Mycoplasma, Klebsiella infections. See link below. "Streptococcus. This ferments to produce large amounts of lactic acid. This may give a tendency to acidosis. Lactic acid is metabolised in the liver by lactate dehydrogenase, so high levels of this may indicate bowel overgrowth with streptococcus. " See more here: http://www.drmyhill.co.uk/wiki/Fermentation_in_the_gut_and_CFS Radio: I feel streptococcal titers, DNase B antibody test and ESR could be good tests to consider. Please post any related research related to this thread. If streptococcal antibody titers are high long term antibiotic therapy could possible help as this is how doctors treat and prevent Rheumatic fever. Streptococcal Antibody Tests Prevention of Rheumatic Fever and Diagnosis and Treatment <---Read this Radio: A.N.D.A.S. Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections? Adult PANDAS: Bare Facts <---Read this!