They are personal to me, but maybe be of some interest to others here... Firstly, if there is any question of heredity of CFS and FMS, I can confirm that it is...My grandfather was married and had two children before he married my grandmother. My cousin, who is the grand daughter of my grandfathers first wife, has CFS,just as I do. Another cousin, who is the grand daughter of my grandfather's second wife, just as I am, has FMS, just as I do. My father, who is that same grandfathers son, was recently dx'd with FMS at the age of 69. My doctors daughter has FMS. What does she has to do with proving heredity in my case? Intererstingly enough, my doctor and his daughter are distant ancestral relatives from the same pedigree line as that same grandfather of mine. So if that doesnt prove heredity, I don't know what does!!!!! So, if someone had the inclination to do the work, conceivably a medical genogram could be generated, and therefore possibly predict the probability of future generations of this family also having it. It could maybe even locate the gene...and maybe a cure or innoculation. I thnk I may present idea to my doctor and see what he says. Now, what worked for me and what didn't so far. I was FINALLY dx'd 6 months ago. I was on flexoril, no dice, amitryp and flexoril, nothing, clonezapam and florinef, nothing. Physical therapy, nothing. Now I am going to begin a course of B12, Paxil, Florinef and Thermotabs to see how that works. Later, MSM(?) might be introduced. The dominate symptoms are excruciating leg aches and pains and inability to sleep more than 4 hours at a time despite complete and total exhaustion. Neck pain is often but not everyday, but when present over rules any other physical symptom I have, and exacerbates sleeplessness. Interesting features of my FMS/CFS/RLS is the occurance of finger tip sized bruises that appear in areas of concentrated pain. Sometimes these "points" are in the typical trigger/pressure points commonly associated with FMS. Most of the time they are somewhere along a radial line of a trigger/pressure point. They begin dark black, then fade to black and blue then to green then to yellow. My skin is especially mottled most of the time. Most prominately on my legs. My eyelids have darkened. I don't mean under eye circles, I have those too, but I mean my eye LIDS. I have postural hypotension, yet no symptoms, like fainting or lightheadness. Just overwhelming sleepiness that could be a symptom but could be the CFS. On a more personal note, my periods are regular with occasional lateness or earliness. But are always painful and heavy. My FMS and CFS symptoms intensify 10 fold during my period. And no matter how much money I spend on razors, I cannot get my legs shaven smooth anymore. Its like the blades can't get close enough to skin. A month and a half ago, while on Clonezapam and Florinef, I began to feel relatively fabulous, not 100% but significantly better as to lift my spirits considerably. It did not last longer than two weeks. I got a sinus infection and totally and completely crashed and my symptoms were more intense than ever and have been ever since. However, ever since, I can tolerate milk products again. If anyone else has ever had any of these same things, drop me a line. Especially the bruising thing..