I was doing some routine sleuthing and the Substance P issue was raised. I happen to think, everything in our body gas an Antagonist. All hormones, neurotransmitters. Negative feed back loops. So what would be a Substance P Antagonist. Turns out the drug Emend (Aprepitant) is a Substance P Antagonist. Aprepitant is available in the market in the treatment of chemotherapy-induced nausea / emesis. So, am wondering if anyone has used this drug, or wondering if this might reduce Substance P, thereby reducing pain? Might be something to research. I go for natural remedies and it seems that Capsaicin has been shown to reduce the levels of Substance P. Many have used this topically with varying degree of success. Capsaicin is also in Cayenne and chili peppers. This can cause irritation in mammels (which we are) but I can't get enough of the hot stuff. Many of you know that I use DL-Phenylalanine for my pain relief. It is an Amino Acid. This is a combination of the D - and L - form of the amino acid Phenylalanine. This form of phenylalanine acts as a natural pain reliever. It will help your body make DOPAMINE AND Endorphins. Endorphins are actually far more powerful than the drug known as morphine. For pain control or as an anti-depressant take 1,000-4,000 mgs twice a day on an empty stomach. (I personally take 1000 mg, in the morning, empty stomach and this is my only pain medication.) It will also help your body make Tyrosine, which converts to the neurotransmitters norepinephrine, epinephrine, dopamine and tyramine. Tyrosine and its metabolites have been shown to support emotional well-being, memory and learning. I would say you will see an improvement the FIRST DAY, and its' effect improve over time. It is available in ANY health food store and costs less than $10. This is a winner!