This is the first time in a LONG time. I hope it wasn't just a coincidence, if I could get to sleeping again I think I would feel much better. I am a little groggy today, and have a "weird" taste in my mouth. My cigs taste funny. I didn't notice yet that I am any less hungry, but I am hoping like heck the weight loss side effect of topamax will hit me too. Maybe the appetite loss is a thing that occurs after you get a build up in your system. I am only to take 25 mgs at bedtime for two weeks then increase to 50 mgs a day. I didn't notice any less pain today either, but it was more tolerable, probably because for the first time in half a year I got more than 4 hours of sleep. Will keep you all posted!!