Hi, I was dx'd with FM in 2003. Take effexorxr and klonopin for pain/depression/anxiety and synthroid for hypothyroidism. I have suffered from migraines for 30+ years and was using Imitrex when the migraines came on. My dr finally said to try topamax. Well...I haven't had a migraine/headache in almost 2 weeks, but the side effects are kinda' weird. Right now I'm on 50mg working my way up to 100mg. My side effects are: the tingles, fatigue, weird taste in mouth, some muscle soreness, and dry skin. Do these subside as your body gets used to the topamax? Does topamax help with the pain of FM (think I read that somewhere?)? I would value your comments and opinions. And yes...I know everyone has different reactions to meds. thanks, ~Cookie~ p.s. This is the first time in about 10 years I've gone 2 weeks without a migraine! WOO-HOO!