About a decade ago, my husband and I met a Traditional Chinese Medicine (TCM) doctor, trained in Taiwan. We were both suffering from serious health problems at the time. My husband had elevated liver enzymes, which had remained constant for over two years. The doctor gave him a formula with a variety of herbs, including bupleurum. Within two months, his liver enzymes were back to normal and have stayed that way ever since. A few years later, I heard in the mass media that a Western study had been done suggesting that bupleurum was indeed effective for liver problems. Further exploration on my part caused me to learn that TCM is reputed to be especially good with regard to helping liver problems (in part because Hepatitis B is extremely common in Asia). This is significant since Western medicine can do little or nothing for them. This was a few months after I came down with CFS, and the doctor gave me a couple of formulae too. I did a whole bunch of things to improve my health at the time, and so I'm not sure how well they worked. Today I was looking through the leftover supplies of herbs that the TCM doctor had given me. I noted that one was called "Special Forumula 9302," and so I made an effort to see if I could find it on the Internet. It turns out that this is a formula developed to help AIDS patients. I don't know that the evidence that it works is conclusive, but here is an article about it. http://www.hkam.org.hk/publications/hkmj/article_pdfs/hkm9906p135.pdf I found this interesting for a couple of reasons: 1) This was in 1995, long before most people had any idea that CFS was related to viral activity (and, like AIDS, is typified by low NKC activity). I did not tell the doctor that I had CFS, and indeed did not know that I did at the time. He prescribed the medication solely based on doing pulse measurements. 2) Although the article above focuses on AIDS patients, it makes one comment about its efficacy with regard to herpes simplex. Obviously this is anecdotal, but nonetheless seems to me interesting. Obviously I'm not saying that people should go out and buy this stuff on their own. Much more than is the case with Western herbs, getting the advice of an experienced practitioner is essential with regard to getting good results. This especially is the case with problems that are more complex, like this one. More common formulae such as ones to improve qi require less knowledge. I will say that I'm intrigued with the concept of TCM though. It's hard to find good practitioners (mine disappeared), especially if you don't speak Chinese. Nonetheless, it conceivably could be worth exploring. It is noteworthy, by the way, that TCM is recognized as a non-alternative and legitimate form of medicine--- practiced alongside Western medicine---in Taiwan. Considering how modern and Westernized Taiwan is in other ways (very close to Japan by now in these respects), that seems to me significant.