I have been taking Tramadol for my pain (with 800mg of motrin) for some time now. I have also been on Prestique for along time also. Recently my doc added Cymbalta. I went to pick up my prescriptions and the Phamacist told me that he has recently went to a siminar and found out that taking Tramadol, Prestiqe and Cymbalta together are not good. He said it can cause you heart to race and irregular heart rate. I was fine before the Cymbalta was added but started to experienced palpatations. This was before the Phamacist told me this. It is really bothering my the arrythmias, they are happening like every minute or more of less but very often. So now I have to go to docs and get that checked out : ( I am decreaseing my Cymbalta dosage too. Has anyone heard of this or expierencing this???