Trichopus zeylanicus - antioxidant, treats fatigue

Discussion in 'Fibromyalgia Main Forum' started by tansy, Sep 25, 2005.

  1. tansy

    tansy New Member

    Antioxidant and DNA protecting properties of anti-fatigue herb Trichopus zeylanicus


    Journal: Phytother Res. 2005 Sep 21;19(8):669-673 [Epub ahead of print]

    Authors: Binu Tharakan [1], Muralikrishnan Dhanasekaran [1 2], Bala V.
    Manyam [1 2 *]

    Affiliations:
    [1] Department of Neurology, Scott & White Clinic and Memorial Hospital;
    Scott, Sherwood and Brindley Foundation, Temple, Texas, USA
    [2] The Texas A&M University System Health Science Center College of
    Medicine, Temple, Texas, USA
    [*] Correspondence to Bala V. Manyam, Department of Neurology, Scott &
    White Clinic/Texas A & M University, 2401 South 31st Street, Temple, Texas
    76508, USA.

    Funded by: Helen Vosburg McCrillus Plummer and Robert Edward Lee Plummer,
    Jr. Endowed Fund

    Keywords: Trichopus zeylanicus • chronic fatigue • antioxidants • DNA
    protection • NADH • polyphenols

    Abstract
    Chronic fatigue is considered a complex symptom for which currently there
    is no curative treatment available.

    Oxidative stress plays an important role in the etiology of fatigue and
    antioxidant treatment might be a valuable therapeutic approach. The Kani, a
    tribal high altitude living population in southern India, traditionally use
    the seeds of Trichopus zeylanicus to combat fatigue.

    In this study, the antioxidant properties of Trichopus zeylanicus were
    established on free radicals (DPPH and ABTS), its ability to reduce iron,
    lipoxygenase activity and hydrogen peroxide-induced lipid peroxidation. The
    effects of Trichopus zeylanicus on reactive oxygen species induced plasmid
    DNA (pBR322) cleavage were also investigated.

    Trichopus zeylanicus significantly scavenged free radicals, reduced lipid
    peroxidation and inhibited lipoxygenase activity. Trichopus zeylanicus also
    exhibited iron-chelating activity and inhibited reactive oxygen species
    induced DNA damage. Trichopus zeylanicus contains NADH, polyphenols and
    sulfhydryl compounds, which have the ability to scavenge reactive oxygen
    species suggesting that the antioxidant activity may be an important
    mechanism of action of Trichopus zeylanicus to combat fatigue.[This Message was Edited on 09/25/2005]
  2. elliespad

    elliespad Member

    thanks tansy, want to email this to myself.