TV Newscaster this morning said there is proof CFS is real

Discussion in 'Fibromyalgia Main Forum' started by NanceZ, Dec 1, 2005.

  1. NanceZ

    NanceZ New Member

    It felt so good to hear that!!!

    I've yet to look up any articles or anything but was so excited I came to post first.

    she said thereis some protein difference in CFS patients.
    so we're on our way to a cure!!!
  2. NanceZ

    NanceZ New Member

    Chronic fatigue gene signs found
    CFS/ME can be debilitating
    Scientists believe they have pinpointed biological markers of chronic fatigue syndrome which could help develop a test and treatment for the condition.

    CFS, or ME, makes people feel extremely tired, and can cause weakness, headaches, and disrupted sleep.

    Scientists, now based at St George's Hospital, London, found differences in the way genes are expressed in white blood cells of people with CFS/ME.

    But others say the New Scientist findings may not explain all cases.

    It is also due to be published in the Journal of Clinical Pathology.

    The scientists say their findings fit with the understanding that a virus, such as Epstein-Barr, may trigger CFS/ME, because that illness might alter how genes are expressed.

    CFS/ME often first appears as a flu-like illness, but does not then go away.


    The researchers compared levels of gene expression in the white blood cells of 25 healthy people and 25 who had CFS using DNA chip technology.

    They found differences in the behaviour of 35 of the 9,522 genes they analysed.

    Further genetic testing showed 15 of the genes were up to four times more active in people with CFS, while one gene was less active.

    Several genes the team pinpointed play important roles in mitochondria, the "powerhouse" of cells.

    One of the products of these genes is EIF4G1, which is involved in the protein production in mitochondria.

    EIF4G1 is hijacked by some viruses, so cells may compensate by increasing gene expression.

    The genetic differences lead to changes in how blood proteins behave which could allow the development of a blood test for CFS, the team say.

    Other genes are involved in regulating the immune system or playing important roles in nerve cells.

    The team will now carry out further research on 1,000 CFS patients and healthy people.

    Not 'made-up'

    Dr Jonathan Kerr who led the research team, which is currently in the process of moving to St George's, said: "The involvement of such genes does seem to fit with the fact that these patients lack energy and suffer from fatigue."

    He added the work could also potentially lead to a treatment for the condition.

    "We have shown that a significant part of the pathogenesis resides in the white blood cells and in their activity

    "It will open the door to development of pharmacological interventions."

    Dr Russell Lane, a neurologist at Charing Cross Hospital, in London, said: "This exciting new work shows that some aspects of this complex illness may be understandable in molecular terms, and that CFS is not a 'made-up' illness."

    Chris Clark, chief executive of Action on ME, told the BBC News website: "The prospect of having a diagnostic test is very encouraging because many people with ME can currently take well over a year to find out what is wrong with them."

    Dr Neil Abbot of Merge, a charity which funds research into CFS/ME, said: "CFS/ME can have very different effects on patients.

    "We're not looking at just one condition with a definitive patient group.

    "So it might be hard to get a gene signature which works for everyone with CFS/ME."

    But he added: "This research probably won't be the answer for everyone, but it is still very interesting."

  3. NanceZ

    NanceZ New Member

    In doing some research I see that this article was posted on this web site back in August....... silly me!

    I'm still happy for the research and findings.
  4. ksp56

    ksp56 Member

    This is GREAT news! Thank you for bumping it up!

    Many times, the consant fatigue from CF is more bothersome than my fibro. If I have a bad flare, then they both like to party in my body!

    Thanks for sharing this!

  5. FibroJo

    FibroJo New Member

  6. xtian1

    xtian1 New Member

    OLD NEWS FOLKS. They are no closer. Think infection.
  7. mbofov

    mbofov Active Member

    Hi Nancez - here is an article I copied from WebMD today which describes proteins found in the spinal fluid of CFS patients. It sounds very interesting to me, and am not sure it is old news as someone else suggested:

    Proteins in Spinal Fluid May Be Markers of Syndrome, Early Tests Show

    Dec. 1, 2005 -- Scientists may have found biological evidence of chronic fatigue syndrome.
    Chronic fatigue syndrome involves severe, unexplained tiredness that lasts for at least six months and doesn't improve with rest.

    Chronic fatigue syndrome often greatly interferes with patients' lives. But it hasn't been well understood from a scientific point of view, and its cause is unknown.
    The new evidence lies in patients' spinal fluid. Tests show 16 proteins in the spinal fluid of people with chronic fatigue syndrome but not in healthy people, according to a study in BMC Neurology.

    Protein Proof

    Of those 16 proteins, five especially stood out. "If you had one of those that was present, then you had chronic fatigue syndrome," researcher James Baraniuk, MD, tells WebMD.

    Baraniuk is an associate professor of medicine at Georgetown University Medical Center.

    "This ushers in a whole new era for identifying [and] recognizing the legitimacy of these disorders,' he says.
    Baraniuk and colleagues compared spinal fluid from 50 people with chronic fatigue syndrome and related conditions to spinal fluid from 22 healthy people.
    The researchers originally recruited people with fibromyalgia or Persian Gulf War illness and later realized that many of the patients had chronic fatigue syndrome.

    "That's very important because it suggests that these are allied disorders," Baraniuk says, adding that the term "Persian Gulf War illness" is no longer used by the U.S. Army.

    Test Not Ready Yet
    Test Not Ready Yet

    "I don't believe there's much value in getting a spinal tap and finding somebody to measure these different proteins," Baraniuk says.

    "First off, it's a research tool. ... You'd have to measure maybe 20 proteins and look at what the pattern is like. We're not there yet in terms of technology to be able to do that."

    He notes that the proteins were identified in two different sets of patients. "The odds of finding these exact same proteins twice [are] astronomical," Baraniuk says.

    Breaking New Ground

    "People generally and many physicians generally believe chronic fatigue, fibromyalgia are not legitimate disorders," Baraniuk says.

    "They sometimes treat these people extremely rudely and don't pay any attention to their symptoms," he continues. "As a result, these patients will go from doctor to doctor. The average is for them to see seven subspecialists a year and have seven different names for the problem."

    "They will be told they have functional disorders, which means there's no test you can do to prove it and there's very few drugs that you can take to improve it," Baraniuk says.

    "But a study like this shows that these people have something in their cerebral spinal fluid that separates them from the normal population," he says.