I thought I would post an update. I've been on Valcyte for two weeks. Other than some increase mood symptoms and a little increased fatigue (and the two episodes of really bad anxiety) I'm tolerating the medication fine. Of course, I'm worried this means I won't be a responder but I've also read that some people don't have the awful reactions and still respond so I'm trying to keep that in mind. So far my bloodwork has been normal. At times I've noticed I feel a little better. I've also been on the simplified methylation protocol for 7 months.