I was prescribed ultram a few weeks ago and am going thru a royal flare now really difficult to stand straight and walk straight even rolling over in bed hurts my hips making sleep elusive at best. Anyway I checked the PDR for all the info on ultram and it says a contraindication is to not take ultram if you are on mao inhibitors or SSRI's meaning antidepressants. it even states not to take it if you are on Zoloft which I am on. So what to do when in pain? I quit my Zoloft because my shrink had told me I am on a very low dose and I would probably need more so now I am still in pain and very depressed.