This is starting my third week on cymbalta. I can't tell a whole lot of difference with the pain yet but i am starting to sleep a little better now. Even though I didn't sleep to well last night, I think it may have had to do with the 1 1/2hr nap I took yesterday when I came in from the dr appt. It is a 2 hr drive 1 way and it just wore me out. I came home and laid cross the bed for just a minute and woke up when the phone rang 1 1/2hr later. I've been having to go to the dr. every week for 4 weeks now i don't have to go back until after Thanksgiving (2 weeks). Then it will be 3 weeks after that so at least i won't have so much traveling to do back and forth. They are surposed to do labs next time to see if everything is still looking good after being on the meds for 4 weeks. I have lost 4 lbs. in 2 weeks because my apetite has decreased. I told the dr. that was 1 side effect that I would happily live with. Maybe i can lose some of these 35 lbs I have gained in the last 7 years since I've had this mess.