I will have taken valcyte 7 weeks this Sunday. I have been told I have CFS/FM, lyme, various bacteria, EB, spinal stenosis, bulging discs, etc. etc (according to all of the pos. test results before starting valcyte)for 23 years. To tell you about myself - I was never sick in my youth. I became a very active professional person - always had to be up and doing something active when I wasn't working - attorney, swimmer, skiier, tennis, jogging, all of it. I became extremely ill in 1984 - flu & pneumonia - which never resolved. Sore throats constantly for month after month, head and neck pain of unusual type, swollen lymph glands, terrible abdominal pain, fatigue, couldn't crawl up the stairs or get out of bed. Bed bound. You know all of the symptoms - and I had them all at one time or another. Horrendous fatigue, that I never could have imagined existed until I exerienced it myself. There's no way anyone can really understand until and unless it happens to them - EVER!) All the different symptoms have been very severe. I have been one of the extremely unfortunate ones to also have unrelenting pain day after day, hour after hour minute after minute. Although it changes, the pain has been the worst symptom for me. It was so severe that I would have tried anything for possible relief. After years of this, I did. I really had no other choice. I had brain and spinal surgery. This is after researching everything, trying everything and every kind of specialist - from MDs. to alternative medical practitioners, every kind of test, diet, herbs, accupuncture, you name it I tried it. After all, I've had YEARS of this and no one was helping me. I would need to help myself because no one else could. Nothing has ever come close to working - until now. I don't know if I will be totally symptom-free, but from the first days of taking valcyte, I knew I felt different, worse actually, but the medicine was doing SOMETHING! From the first weeks, I was having the herx reactions and it was bad and its getting worse. But I actually experienced periods of time where I felt almost normal and this hasn't happened in 23 years. It was ME; I was back during those hours. I was back to my old self that I had prayed for, for all these years. For periods of time over 2 or so days I went non-stop and was it WONDERFUL! Its so hard to explain, especially since I am still taking narcotics for pain, and even though I am herxing and the symptoms are twice as bad as when I had started taking valcyte, I feel that this may be the start of my eventual recovery. Those few days have given me the hope that I may actually get well.