Ventricular cerebrospinal fluid lactate increased in ME/CFS

Discussion in 'Fibromyalgia Main Forum' started by tansy, Oct 26, 2008.

  1. tansy

    tansy New Member

    Ventricular cerebrospinal fluid lactate is increased in chronic
    fatigue syndrome compared with generalized anxiety disorder: an in
    vivo 3.0 T (1)H MRS imaging study.

    Journal: NMR Biomed. 2008 Oct 21. [Epub ahead of print]

    Authors: Mathew SJ, Mao X, Keegan KA, Levine SM, Smith EL, Heier LA,
    Otcheretko V, Coplan JD, Shungu DC.

    Affiliation: Department of Psychiatry, Mount Sinai School of
    Medicine, New York, NY, USA.

    NLM Citation: PMID: 18942064

    Chronic fatigue syndrome (CFS) is a controversial diagnosis because
    of the lack of biomarkers for the illness and its symptom overlap
    with neuropsychiatric, infectious, and rheumatological disorders.

    We compared lateral ventricular volumes derived from tissue-segmented
    T(1)-weighted volumetric MRI data and cerebrospinal fluid (CSF)
    lactate concentrations measured by proton MRS imaging ((1)H MRSI) in
    16 subjects with CFS (modified US Centers for Disease Control and
    Prevention criteria) with those in 14 patients with generalized
    anxiety disorder (GAD) and in 15 healthy volunteers, matched
    group-wise for age, sex, body mass index, handedness, and IQ.

    Mean lateral ventricular lactate concentrations measured by (1)H MRSI
    in CFS were increased by 297% compared with those in GAD (P < 0.001)
    and by 348% compared with those in healthy volunteers (P < 0.001),
    even after controlling for ventricular volume, which did not differ
    significantly between the groups. Regression analysis revealed that
    diagnosis accounted for 43% of the variance in ventricular lactate.

    CFS is associated with significantly raised concentrations of
    ventricular lactate, potentially consistent with recent evidence of
    decreased cortical blood flow, secondary mitochondrial dysfunction,
    and/or oxidative stress abnormalities in the disorder.

    Copyright (c) 2008 John Wiley & Sons, Ltd.
  2. simonedb

    simonedb Member

    hey this seems interesting, my sx definitely wax and wane with my spinal issues and cranial sacral body work can help or hurt, sometimes it has flared me for months!
    I dont know if that would tie in, can you say more about what you think this means in laymens terms and what implications for treatment you think?