Vitamin C for Cancer.

Discussion in 'General Health & Wellness' started by gapsych, Feb 4, 2011.

  1. gapsych

    gapsych New Member

    Out of respect for MsE. I am starting a separate thread on here as I don't want to detract from the subject of her post.

    I don't particularly want to debate this but you guys can have at it.

    . Mayo clinic has also done a lot of studies. No therapeutic effect as an adjunct therapy and according to the following study may even hinder the effectiveness of treatment of chemotherapy. As I said, I will start a separate thread.

    However, all the studies cited, including mine are only preliminary, in vitro or not true DBR studies.

    Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs.
    Heaney ML, Gardner JR, Karasavvas N, Golde DW, Scheinberg DA, Smith EA, O'Connor OA.

    Departments of Medicine and Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

    Comment in:

    Cancer Res. 2009 Nov 15;69(22):8830; author reply 8830-1.

    Vitamin C is an antioxidant vitamin that has been hypothesized to antagonize the effects of reactive oxygen species-generating antineoplastic drugs. The therapeutic efficacy of the widely used antineoplastic drugs doxorubicin, cisplatin, vincristine, methotrexate, and imatinib were compared in leukemia (K562) and lymphoma (RL) cell lines with and without pretreatment with dehydroascorbic acid, the commonly transported form of vitamin C. The effect of vitamin C on viability, clonogenicity, apoptosis, P-glycoprotein, reactive oxygen species (ROS), and mitochondrial membrane potential was determined. Pretreatment with vitamin C caused a dose-dependent attenuation of cytotoxicity, as measured by trypan blue exclusion and colony formation after treatment with all antineoplastic agents tested. Vitamin C given before doxorubicin treatment led to a substantial reduction of therapeutic efficacy in mice with RL cell-derived xenogeneic tumors. Vitamin C treatment led to a dose-dependent decrease in apoptosis in cells treated with the antineoplastic agents that was not due to up-regulation of P-glycoprotein or vitamin C retention modulated by antineoplastics. Vitamin C had only modest effects on intracellular ROS and a more general cytoprotective profile than N-acetylcysteine, suggesting a mechanism of action that is not mediated by ROS. All antineoplastic agents tested caused mitochondrial membrane depolarization that was inhibited by vitamin C. These findings indicate that vitamin C given before mechanistically dissimilar antineoplastic agents antagonizes therapeutic efficacy in a model of human hematopoietic cancers by preserving mitochondrial membrane potential. THESE RESULTS SUPPORT THE HYPOTHESIS THAT VITAMIN C SUPPLEMENTATION DURING CANCER TREATMENT MAY DETRIMENTALLY AFFECT THEREPUTIC RESPONSES. (Bold mine.)

    By the way, science based medicine has discredited Linus Pauling.

    [This Message was Edited on 02/04/2011]
  2. TwoCatDoctors

    TwoCatDoctors New Member

    The one doctor of mine underwent surgery for cancer and they are doing radiation on him now. I was interested to see if alternate therapies are being proposed and asked him today if they had proposed any other types of treatment for him, like supplements instead of surgery or supplements instead of radiation and he said no.
    [This Message was Edited on 02/04/2011]
  3. mbofov

    mbofov Active Member

    Here are links for several studies which show promise for the use of intravenous vitamin C in the treatment of cancer. The Mayo Clinic studies which failed to show any benefit from vitamin C were fatally flawed because they only used oral doses of vitamin C and not intravenous. Much higher levels of vitamin C can be achieved via the IV route. - Mayo Clinic studies oral use only