I have just switched from zoloft to wellbutrin, and went from 150 mg of wellbutrin to the 300 mg, and it made me feel AWFUL! Sort of speedy, and freaking out at times, and like I needed to pace the floor. I think that 300 mg was just WAY too much. So, today I went back to the 150 mg pill, and will call the Dr tomorrow, but I was curious as to how much the rest of you were tolerating. It seems to be very powerful, and as you know, we are usually sensitive to drugs, anyway. I do have to say that the energy boost is better than zoloft ever was- I couldn't drag myself around with that junk any more, and I blew up like a balloon on zoloft, too. Here's hoping that today will be better than yesterday with this drug.