Lyme Disease – Its Cause, Symptoms and Treatments: (Please review link) "Dr. Nicolson's research demonstrates that cell & mitochondrial membranes, impaired by excess oxidative stress in Chronic Lyme & other diseases..." "This interview highlights key points in Dr. Nicolson's presentation to the ILADS group - “Reversing Mitochondrial Damage and Increasing Cellular Energy in Chronic Lyme and Lyme-Associated Infections.” What happens if Lyme disease is left untreated? Prof Nicolson: Chronic LD can progress to a fatal disease, but most patients become slowly disabled and are often diagnosed with other diseases or syndromes, such as Chronic Fatigue Syndrome, neurodegenerative diseases, Rheumatoid Arthritis or other diseases or illnesses. In the most severe forms, Chronic LD patients can have multiple diagnoses, and this form of LD is particularly difficult to successfully treat. * * * * Q: Have you done any clinical studies with patients with Lyme disease? Prof Nicolson: Most of our studies on Chronic LD have involved the laboratory diagnosis of various co-infections, such as Mycoplasma species, in Chronic LD using molecular genetic methods. • For example, we were among the first to identify various Mycoplasma species in Chronic LD patients and determine the incidence of these co-infections among LD and non-LD patients. • We also studied the incidence of various LD-associated infections in other diseases, such as Chronic Fatigue Syndrome [ME/CFS], Fibromyalgia Syndrome, Autism Spectrum Disorders, etc. This has resulted in our suggestion that various LD-associated infections are very common in many chronic diseases. I have recently reviewed this topic, and copies of this two-part review in the British Journal of Medical Practitioners can be down-loaded from our website, www.immed.org. [“Role of Chronic Bacterial and Viral Infections in Neurodegenerative, Neurobehavioral, Psychiatric, Autoimmune and Fatiguing Illnesses: Part 1 and Part 2.] We have also worked on chronic fatigue and mitochondrial dysfunction in Chronic LD and other diseases and illnesses, and how this can be corrected. • Mitochondria in our cells provide the high-energy molecules necessary for cellular metabolism and life. • In Chronic LD and many other infection-based diseases, the mitochondrial membranes are damaged by oxidative stress, resulting in leakage of the membranes and an inability to produce high-energy molecules. • In patients with Chronic LD the mitochondria are only functioning at about one-half their normal capabilities, and this results in and is perceived as chronic fatigue. Q: Often fatigue is a major issue in Lyme disease, along with muscle weakness and headaches. Is there anything that can be done to assist with these symptoms as one is healing? Prof Nicolson: We and other LD experts have shown that chronic fatigue, muscle weakness and other symptoms in Chronic LD are related to loss of mitochondrial function. This is where our research with patients who have other chronic illnesses, such as Chronic Fatigue Syndrome [ME/CFS] and Fibromyalgia Syndrome, has helped in Chronic LD. All these patients have somewhat similar problems with excess oxidative stress and damage to their mitochondria. We have found that Lipid Replacement Therapy with oral NT Factor® (the replacement of damaged mitochondrial membrane lipid components with undamaged membrane phospholipids) can restore mitochondrial function and significantly reduce fatigue. [See “Repair Damaged Mitochondria and Reduce fatigue Up to 45%: The Story Behind NT Factor,” Aug 6, 2010.] Q: How can repairing cell membranes help someone with Lyme disease? Prof Nicolson: As in other chronic diseases, cellular membranes in Chronic LD patients are often damaged by excess oxidative stress, especially the very sensitive cellular membrane and mitochondrial membrane phospholipids. These phospholipid molecules form the matrix or main barrier of all of our cellular membranes, and when they are damaged by oxidation, they allow our membranes to become leaky and permit ions and other small molecules to leak out of our cellular organelles such as mitochondria and even our cells. It is especially important in nerve cell membranes, as well as in the membranes in various cells of the immune system, that membrane barriers provide electrical and ionic differences across the membranes. When the membranes leak, cellular function is impaired. We have used Lipid Replacement Therapy with oral NT Factor to help restore cellular membranes and especially membrane function. In patients with Chronic LD as well as other chronic diseases, restoring membrane function resulted in significantly reduced fatigue and better functioning cells. This translated into better quality of life. * * * * End quote"