I realize fatigue is our first sign, however we are always fatigued ! what I mean is that sometimes there are other signs and symptoms of major relapse. I know for me it is a sore throat and not the kind where you're getting a cold sore throat either. You just know the kind right away, following it is either a weak voice or loss of voice completely. It is funny how others are always telling me "Oh you've got another cold, you better do something about that" when in fact I ve had this for years, and they still have not listened to me, goes to show you how others are not really listening to us. I have come to realize we are in this together and that is about it, cuz I ve witnessed over and over for years of being diagnosed with this, that really no one will really understand us, but US... what are some of your first signs and symptoms I am just curious.