Hey all. I've had a long standing problem with drug intolerance etc. Even supps. Apart from being so sensitive, I have a strange problem that alot of drugs / supps are metabolized EXTREMELY slowly in my body. If the expected time to feel a drug effect is say, 1-3 hours in a normal person, it will take about 8-12 hours for me to feel it. I believe this is the major problem with my current cortisone therapy. Its taking so long to metabolize and process before i feel the effect, that it's literally nearly bedtime for the day before i feel it after taking it all day long. I lay around feeling soo sleepy, irritable, weak arms and legs, and generally ill. Finally.. somewhere between 6pm and 8pm, i start feeling like i can breathe a bit better, my mind wakes up some, and i have some feelings of stability, being able to get up and do a few things like eat and have a shower. Not every day, but more days now im getting this tiny window. However, I hate that it takes ALL DAY before i feel any effect. It's the same in the past for things like B complex.. generally if i took a strong b complex, i would get bad headaches and some nausea, generally not feel well, but about 5 hours later i would feel better in the body than usual. Difflucan is another one.. one dose, and I felt absolutely dreadful all day - extremely nauseous, heavy and weak, unable to eat, severe brain fog, just generally sick all over. That goes all day, however, the day after I felt wonderful, like it had really started killing that systemic low level fungal infection. Then theres other drugs, like Zyrtec (antihistamine), and zantac (stomach acid) which work just fine within 20 minutes just like everyone else. My only theory is that my liver doesn't detox well at all (which it doesnt, even though i take liver support tablets, and have done liver detox kits etc).. However, I would really love to hear any other opinions on why a body would process things SO slowly! Is there any specific weird conditions that causes this slow metabolism? My theory is if I could improve this drug metabolism, I would possibly need alot less cortisone and it would work much better for me all day long. However, it has been like this for about 7 years now and Im really not sure this type of thing can be improved so easily. Thanks.. ~Chris.