My husband suffers from extreme irritability and defensiveness which has made my illness so much worse due to stress. He has finally agreed to talk with family doc about medication. Can anyone give me input on what meds might work well for these symptoms. I have been reading about Buspar, Wellbutrin, and Serzone. Has any one had luck with these meds for these symptoms? Family doc is willing but not had a lot of experience. I am so afraid the wrong med might make him worse and what it would do to my already fragile existence.