Why amitryptiline is not advised in ME/CFS

Discussion in 'News and Research' started by IanH, Feb 8, 2014.

  1. IanH

    IanH Active Member

    Amitryptiline and possibly other antidepressants such as fluoxetine (prozac) have been shown to affect mitochondrial function. Amitryptiline reduces CoQ production, increases lipid peroxidation and ROS production. The very changes you do not want in ME/CFS. It may also reduce respiratory chain function resulting in lowered ATP production (lowered energy availability).

    This can be attenuated with the addition of CoQ10 and vitamin E. So if you are on antidepressants and you have ME/CFS then it would be wise to take CoQ10 (ubiquinone 150mg twice daily or ubiquinol 100mg daily) plus vitamin E 400IU daily.

    Refs:
    In vitro inhibition of mitochondrial respiratory rate by antidepressants
    Jana Hroudová, Zdenek Fisar.
    Toxicology Letters 213 (2012) 345–352, Elsevier

    The In Vitro Effects of Tricyclic Drugs and Dexamethasone on Cellular Respiration of Malignant Glioma
    S.C. HIGGINS and G.J. PILKINGTON
    Anticancer Research February 2010 vol. 30 no. 2 391-397

    Coenzyme Q(10) and alpha-tocopherol protect against amitriptyline toxicity
    Cordero, M.D. etal
    Toxicol. Appl. Pharmacol. 235(3):329-337
    spacee and bct like this.
  2. punkin1955

    punkin1955 Member

    HI LUPUS FIBROMYALGIA CHRONIC INSOMNIA SLEEP APNEA RLS TMJ