Methylation support is a long term strategy needed to support detoxification that may help silence viruses. I will try to give you a good analogy why Methylation is important in FM. (as you may know) The older we get the more susceptible we are to developing the dreaded shingles virus (if) we had an exposure to chicken pox as a kid. The reactivation of the virus can be associated with methylation insufficiencies very common in our elderly population. The key point I am trying to make is RNA/DNA (need Methyaltion) to help silences viruses and rebuild the body. You can now see how import this can be as viruses have been implicated as a possible trigger in FM. I want to add, Methylation is also needed for Myelination as vitamin B12 and Iodine are important co-factors. How do we test for Methylation insufficiencies? The Homocysteine and Methylmalonic Acid are common test that any doctor can run. I want to stress that these two test are important establishing possible Methylation insufficiencies. There will always be complexes to any solution and variations to all healing strategies. The key to healing the body is understanding the contributing factors and putting the pieces back together in the right order. Start here: Methylation Made Easy | ProHealth ME/ CFS Note* We also need Methylation for detoxification as well -aka- Glutathione Symptoms of Vitamin B 12 Deficiency Active B12 therapy and methylation FAQ - Diagnosing and Treating Vitamin B12 Deficiency Vitamin B-12 Supplement - Methyl B-12 by ProHealth MTHFR Defect | Dr. Paul's a MUTANT & You Might Be Too + Why It's Important To Know Methylation and MTHFR Defects presented by Benjamin Lynch, ND See more here: MTHFR Mutation | MTHFR Gene Mutation | What is MTHFR?