I've gained 50 pounds in 3 years on Effexor. It's very uncomfortable since I'm usually an average size and active person. Since fibro, things have changed though. I'm currently trying to come off of Effexor and as many of you know it is a very slow and long process due to the side effects. To those who have gone through it, I am wondering if the weight loss is really tough after you are off the effexor? I have tried weight watchers and other diets and can't lose while on it.