Symptoms of Heart Disease — For Women Women may experience early symptoms of cardiovascular disease differently than men. The symptoms in women can be far subtler. If you or any woman you know shows these signs, seek medical attention right away. Shortness of breath, often without chest pain of any kind Flu-like symptoms — specifically nausea, clamminess or cold sweats Unexplained fatigue, weakness or dizziness Pain in the chest, upper back, shoulders, neck, or jaw Feelings of anxiety, loss of appetite, discomfort If you even suspect these symptoms, call your doctor. If urgent, call 911 (or your local emergency number if outside the U.S.) or go to a local hospital's emergency room. If you have any doubts, talk to your healthcare provider.