xango juice

Discussion in 'Fibromyalgia Main Forum' started by spmary, Oct 10, 2005.

  1. spmary

    spmary New Member

    Has anyone heard of xango jiice? And please tell me about it..Thanks, spmary
  2. Grandma6

    Grandma6 New Member

    I have never heard of it but you got my curiosity up so I went online and typed in "xango juice" and there is a load of info on it.
    The fruit that the juice comes from is called Mangosteen & mostly grows in South East Asia, (Thailand, India, Vietnam& some in Hawaii). It's the size of a mandarin and is known to help in a lot of medical areas.
    Here's just a few:
    Increase energy
    Good for the immune system
    promates joint flexibility
    Provides positive mental support
    and many, many more.

    I would suggest you go to your favorite search engine and type it in and take it from there.

    Have a Good Night,
    Grandma6
  3. victoria

    victoria New Member

    Seems like the latest multilevel marketing health product craze, Mary, in my opinion - hard to say what if anything it would do.

    I found a good article that I excerpted below with the most important info (almost all about helping cancer)... this doctor also has a website you could google for. This may be more than you'd ever want to read about it LOL, but I found it actually pretty interesting!
    ---

    A Friendly Skeptic Looks at Mangosteen

    By Dr. Ralph Moss, from CancerDecisions Newsletter

    One of the latest (cures)... is an exotic fruit drink called mangosteen, or XanGo. Mangosteen should not be confused with mango, an entirely different plant.

    No one knows exactly where and when the mangosteen was first cultivated. .. But attempts continued to bring mangosteen to Europe and America as a food. "Despite the oft-repeated Old World enthusiasm for this fruit," says Morton, "it is not always viewed as worth the trouble to produce. In Jamaica, it is regarded as nice but overrated; not comparable to a good field-ripe pineapple or a choice mango."

    ... The pulp ... said to resemble a pineapple or peach in taste, is reputed to be a very delicious food - in Asia it is sometimes called the queen of fruits in honor both of its flavor and its economic importance.

    Uses in Traditional Medicine

    For many years dried mangosteen fruits have been shipped from Singapore to Calcutta and then on to China for medicinal use. As to its many uses in folk medicine, here is what botanist Julia Morton has written:

    "The sliced and dried rind is powdered and administered to overcome dysentery. Made into an ointment, it is applied on eczema and other skin disorders. The rind decoction is taken to relieve diarrhea and cystitis, gonorrhea and gleet [a watery discharge, ed.] and is applied externally as an astringent lotion. A portion of the rind is steeped in water overnight and the infusion given as a remedy for chronic diarrhea in adults and children.

    "Filipinos employ a decoction of the leaves and bark as a febrifuge and to treat thrush, diarrhea, dysentery and urinary disorders. In Malaya, an infusion of the leaves, combined with unripe banana and a little benzoin is applied to the wound of circumcision. A root decoction is taken to regulate menstruation. A bark extract called 'amibiasine', has been marketed for the treatment of amoebic dysentery."

    Morton also writes that "[t]he rind of partially ripe fruits yields a polyhydroxy-xanthone derivative termed mangostin, also beta-mangostin. That of fully ripe fruits contains the xanthones, gartanin, 8-desoxygartanin, and normangostin. A derivative of mangostin, mangostin-e, 6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure." A more complete listing of constituents is given at ethnobotanist Dr. James Duke's informative and useful Phytochemical and Ethnobotanical Databases (Duke 2004).

    We can conclude then that mangosteen has many uses in folk medicine, and as such, it can join a fairly long list of plants that can be considered as promising sources of new medicines.

    XanGo on the Go

    In this age of frenzied commercialism, entrepreneurs are always on the lookout for ways to make it big in the natural medicines market. Under such conditions, however, new medicines of botanical origin cannot be developed or tested in an orderly way.

    A common feature of the way in which natural medicines such as mangosteen are promoted is the use of network marketing. This involves the retailing... through the use of independent distributors (that) are then encouraged to build and manage their own sales force by recruiting, motivating, supplying, and training others to sell products. Compensation in such arrangements includes the distributor's own sales as well as a percentage of the sales of his or her entire "downline" (i.e., all those people signed up by an individual, who in turn go on to become salespeople)...

    ...A sophisticated marketing blitz, including books and pamphlets, seemingly objective newsletters, press releases and chattering websites, inflate the importance of a product, creating a buzz that only dies away when the huge supply of potential customers and salespeople is finally exhausted. Or when... the government finally steps in. But the essential requirement for a successful MLM operation of this sort is a kernel of promising-sounding scientific evidence, coupled with a credible and compelling story...and finally some patients... willing to testify that the product led to astounding cures.

    ...The techniques of network marketing... are now being used by a Utah-based company to position mangosteen as the latest "miracle cure" craze. The price of their XanGo mangosteen juice is currently $37 per bottle... The reason the marketers can succeed in selling juice at this price is obvious: when people are suffering from medical conditions for which there does not appear to be much hope, or for which the orthodox medical recommendations are too toxic or expensive, they will actively seek alternatives...

    Xanthones

    As stated, one requirement ... is that there be at least a kernel of scientific truth around which exaggerated claims can be assembled. ...mangosteen is not entirely without scientific documentation. The problem, as usual, is that the claims for mangosteen are inflated till they far outpace what has been established through careful experimentation.

    Some mangosteen promoters have mined James Duke's famous ethnobotanical database for confirmation of their product's value. And, indeed, Dr. Duke confirms that the plant contains several interesting components. But so do thousands of other plants in his voluminous database. For most of the chemicals contained in this fruit (such as beta-mangostin, catechins, cis-hex-3-enyl-acetate, gamma-mangostin, gartanin, garcinones) the database lists NO particular biochemical activities.

    Only the compound called "mangostin" seems to have some scientific backing for its antibacterial, antiseptic and fungicidal properties (Recio 1989). Yet scores of mangosteen websites now cite Duke's database as scientific justification for this product. In reality, Dr. Duke has absolutely nothing to do with any mangosteen distributor and is not particularly enthusiastic about the product.

    Much is made of the xanthone connection. According to the MyXanGo website ...But all of this is speculative. It is undoubtedly true that there are many xanthones (a kind of antioxidant) in mangosteen.

    In fact, according to the Merck Index (11th Ed., p. 5613) the first scientifically defined substance to be derived from mangosteen was the xanthone mangostin... in 1855. In 1979, mangostin was found to have significant anti-inflammatory and anti-ulcer effects in rats (Shankaranarayan 1979).

    Yet although mangosteen's xanthones have been known for almost 150 years, there are still only 19 PubMed articles on these xanthones and none of these articles concerns the use of xanthones in the actual clinical treatment of human disease. So I would say the jury is still out on their effectiveness in treating anything.

    The main XanGo website also claims that the antioxidant ORAC (oxygen radical absorbance capacity) value of mangosteen is the highest of all edible plants...Many other XanGo - promoting websites repeat the claim that while the previous champion, prunes, have an ORAC value of 7,000 per ounce, mangosteen has an ORAC value of 17,000 to 24,000.

    Yet XanGo sites claim that "a new champion" has been born in the worldwide contest for ORAC supremacy. But where in the scientific literature is the ORAC value of XanGo published? The source of these numbers is hard to track down. For instance, the Sunsweet prune website states that 100 grams (3.5 ounces) of prunes have an ORAC value of 5,770.

    While the ORAC values for most fruits and vegetables have been determined by standard laboratories and published in scientific journals, this is not so for mangosteen. I have not seen independent confirmation of these confidently promulgated claims. However, ... it must be pointed out that merely having an astronomically high ORAC value does not (necessarily) in and of itself confer any particular advantage. Not all antioxidants that are confirmed as present in the laboratory can be absorbed by human beings. And there is a limit to how much we can benefit from an increased intake of antioxidants.

    According to Dr. Ronald Prior of the US Department of Agriculture Research Service at Tufts University, Boston, Massachusetts, "a significant increase in antioxidants of 15 to 20 percent is possible by increasing consumption of fruits and vegetables, particularly those high in ORAC value."

    However, in order to have a significant impact on plasma and tissue antioxidant capacity one can only meaningfully increase one's daily intake by 3,000 to 5,000 ORAC units. Any greater amount is probably redundant. That is because the antioxidant capacity of the blood is tightly regulated, says Dr. Prior. Thus there is an upper limit to the benefit that can be derived from antioxidants. Taking in 25,000 ORAC units at one time (as reputedly occurs with mangosteen) would be no more beneficial than taking in a fifth of that amount: the excess is simply excreted by the kidneys.

    ...Although I myself have written a book on the subject of the benefit of antioxidants (Antioxidants Against Cancer), I would say it is a tremendous stretch to claim that antioxidants are predictably going to save anyone's life. Good health is achieved through a combination of many factors, hereditary as well as environmental.

    Effects on Cancer

    At the XanGo website, a company spokesperson interviews Dr Templeman on the subject of mangosteen's beneficial effect on cancer. They both agree that a SINGLE TEST TUBE EXPERIMENT (caps mine-V) is proof of the anticancer value of the juice:

    Dr. Templeman: "That's striking."

    XanGo spokesperson: "It's incredible."

    At various other websites devoted to XanGo (and there are now over 21,000 of them!) we read in glowing terms about both the supposed quantity and quality of scientific research on this previously obscure fruit.

    Reality Check

    So it is high time for a reality check. Has mangosteen really been thoroughly studied in terms of its effect on cancer and a host of other diseases? Or is this simply a wild extrapolation driven by strong commercial motives?

    Dr. Templeman refers to 44 scientific publications on this topic but there are just 29 articles on the topic of Garcinia mangostana in PubMed, the US National Library of Medicine database of 14+ million citations. A total of four of these studies relate to cancer. In one test tube experiment it was shown that a xanthone found in mangosteen kills cancer cells as effectively as many chemotherapeutic drugs. It also appears (on the basis of limited data) that compounds found abundantly in mangosteen can inhibit the harmful Cox 1 and Cox 2 enzymes, and can also induce programmed cell death (apoptosis) in aberrant cells (Ho 2002). Mangosteen thus joins a fairly long list of naturally derived compounds that might potentially have some anticancer activity.

    These 29 articles do not constitute a wealth of data. For example, by contrast, PubMed lists over 2,300 articles on the topic of vitamin C and cancer, 125 of which refer to clinical trials. There are a similar number of studies on vitamin E and cancer. There are 835 studies of melatonin and cancer, and a truly impressive 16,000 on polysaccharides and cancer, including 536 clinical trials and 277 randomized controlled trials (RCTs).

    Yet, we're to believe that four test-tube experiments constitute - to quote the aforementioned Dr. Templeman - "mountains of evidence" on the benefits of XanGo.

    ...Yet despite the website's misleading talk about "clinical studies," PubMed does not contain a single clinical trial of mangosteen in the treatment of cancer, or any other disease. Perhaps these promoters don't realize that a clinical study is not something done in a laboratory, but a study that by definition is carried out on living patients. Laboratory studies on cell lines or even animals do not qualify for the title 'clinical study'.

    Thus, despite what you may read at any one of those 21,000 promotional websites, very little scientific evidence exists concerning mangosteen's anticancer activity in humans.

    Compounds found in plants have long been of great interest to cancer researchers. We must never forget that about one-fifth of all chemotherapeutic agents... are ultimately derived from plant sources... the riches of the natural world are often neglected by mainstream science, only to be plundered by less scrupulous organizations. The patient loses twice - by not having the fruits of serious research and by being deceived by slick operators posing as friends and benefactors. Some may even opt for unproven miracle juices in lieu of more certain therapies that might save their lives.

    When it comes to cancer, we truly live in a topsy-turvy world.

    References:

    Campin, Jac. Guide to Plant Relationships (for food allergy and intolerance identification),Version 12 (14 April 2004. Retrieved April 27, 2004 from: http://www.purr.demon.co.uk/Food/RelatedPlantList.html

    Duke, James, ed. Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture, Agricultural Research Service, Accessed April 27, 2004 from: http://www.ars-grin.gov/cgi-bin/duke/farmacy2.pl?1228

    Hedrick, U.P. (ed.) 1972. Sturtevant's Edible Plants of the World. NY, NY: Dover Publications, Inc., 1972. Downloaded from: www.swsbm.com/

    Ho CK, Huang YL, Chen CC. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med. 2002 Nov;68(11):975-9.

    Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y. Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod. 2003 Aug;66(8):1124-7.

    Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004 Jan;90(1):161-6.

    Morton, Julia F. Mangosteen. In: Fruits of Warm Climates. Self-published. Miami, FL, 1987, pp. 301-304. ISBN: 0-9610184-1-0

    Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem Pharmacol. 2002 Jan 1;63(1):73-9.

    Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research. 1989:3(4)117-125.

    Shankaranarayan D, Gopalakrishnan C, Kameswaran L. Pharmacological profile of mangostin and its derivatives. Arch Int Pharmacodyn Ther. 1979 Jun;239(2):257-69.
    -----------------

    Hope this helps you, Mary... sounds like more hype than substance to me personally, at least at this point.

    All the best,
    Victoria


    [This Message was Edited on 10/10/2005]
  4. orachel

    orachel New Member

    called something like "better after 10 years".

    10 year sufferer took mangosteen, along with a combination of daily massages (from a family member) with Castor oil, and 2 hours on heating pad. She also took approx 24 fish oil capsules per day (but you do have to have a test done to see how much fish oil your body can tolerate). This member (her name escapes me, but look up the post!) had seen a near Miraculous recovery. She was initially nothing but a disbeliever in this type of treatement as after suffering for 10 years she'd tried everything with little result...her mom "bullied" LOL her into trying this basically by saying "i love you, now lie down so I can rub this oil on you" LOL

    I just ordered a large quantity of castor oil for my godmother to rub me down (must get bigger quantities ordered from pharmacy...usually its taken by the spoonful internally, so can usually only be found in 3 oz size...much to small for daily massage! I ordered 24 oz for like 19$...mangosteen is somewhat expensive, but her mother bought her the first 4 bottles for abt 140$, and that lasts quite a while.

    I'm starting with the castor oil rubs (as that is a relatively common school of thought for overall health from many alternative med providers), then adding in much more fish oil...already take 2 capsules daily, then adding the mangosteen.

    Look up the post...if this works 1/10 as well for me as it did for her, she'll be my most effective treatment provider to date! lol

    Rachel
    [This Message was Edited on 10/10/2005]
  5. spmary

    spmary New Member

    Thanks so much for the replyies. The only site I got seemed to be for hiring dealers. I didn't want that. I had heard that some doctors in N C were using it and prescribing it for some of their hospital patients. Some one wanted me to take it, but I wanted to know more, so thanks so much! ,Mary

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