Question: The big three, plus xyrem & others being tested in clinical trials. What criteria would a person use in agreeing to try one? Reply: This would vary, depending on the trial. Some trials are very restrictive in patient recruitment, and participants have to agree to a number of stipulations before they can enter the trial. You should carefully examine the trial and agree to the goals, expected outcomes, agreements, design, restrictions, exclusions, evaluations, possible adverse side effects, compliance and other factors before joining a clinical trial. If there is anything that bothers you about the trial, don’t sign up. Don’t do it unless you are committed to completing the trial. One of the biggest problems in conducting clinical trials is that patients decide during the trial to quit, or they do not follow the trial guidelines. For example, in running clinical trials on chronic fatigue, CFS or FMS patients, we generally have to recruit at least 20-25% more patients than necessary to fulfill the statistical goals of the trial because of compliance issues and loss of patients during the trial.