I have taken the muscle relaxer zanaflex and also flexril many times and neither has ever done me any good. I couldn't even tell when I take them. I had a prescription my rheumy wrote last october for zanaflex and I thought I would get it filled last week to see if it would help with my shoulder and neck pain. I was cooking dinner, for the first time in weeks, and I took a pill. In the middle of dinner I started feeling loopy and high. I couldn't even sit there. I went to the couch and could barely hold my eyes open. They felt swollen and I felt like I was in a dream. I lay there and slept off and on for hours. One time when I woke up I saw a big spider hanging over my head. (I have done this in the past without any influence of medication. I sometimes will be paralyzed in sleep and see bugs and they look so real) I started yelling and swiping at the air and my husband asked me what I was doing. I told him there was a spider there and he said no there wasn't. He said he had waved his hand in front of my face to see if I was awake or not because my eyes were half open. I felt drugged up until just a little bit ago. I can't believe it affected me that way and it never did anything before. At least the pain went away for a little while. I don't think I can take it anymore unless I am going to bed. By the way my mom came right in the middle of this and I am sure this just added to her thinking I take too many drugs. I don't take any kind of pain meds. I have had a propoxy tablet in a bottle for months and havent' taken it. They really don't seem to help a lot so I don't bother. The one night I take something this has to happen! LOL! Has anyone else had this happen with zanaflex. Have you taken it one time and it do this and another it not?