To all who may be intrested: I am new to this site and dd but I have been rx'd zyrem. So, I thought I would share what I know about it. Zyrem is a highly controled narcolepsy drug. Its use in treatment of CFS & FM is considered off label (not approuved by FDA for this illness). Zyrem is commenly known in the drug world as GHB. Prior missuse of this drug has made it now highly controlled. Due to this, there is only one pharmacy in the US where this medication can be purchased and few doctors are willing to perscribe it (due to it being off label). My own experience was that I had to have a sleep study done to have my doctor rule out any other problems prior to him rx'ing same. I have been told that due to the control issues surrounding zyrem it could take up to one month for me to finaly receive my first dose. As for cost, because it is an off label use (not ok'ed by FDA for us) most insurance companies will not cover the RX. In that case, the cost without insurance could be as much as $300.00 a month. The good news is that my doc has treated 5-6 other FM/CFS people and all have showed glowing results. Virtually all have fully recovered from there major problems with the occasional set back or flare up. My doc is hopeful that within the next several years zyrem will be ok'ed for use with FM & CFS and then would be more accesible to all who could benifit from its use. I hope this has been helpfull......maybe you can take this information and share it with your doc and see what he/she thinks. Maybe you can benifit from it too!!! Have a great day! Gladeone P/S when I get my RX I'll keep the site posted on how it's going.