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  1. R

    For those with CFS who have done 23andMe testing...

    I would ask to be referred to an immunologist. Allergy and immunology are the same specialty, but most doctors go on to only treat allergy patients and not immune deficiencies. There is a good organization you might want to contact and see if they can recommend a doctor in your area. It's...
  2. R

    For those with CFS who have done 23andMe testing...

    The best way to get diagnosed is a good immunologist who specializes in immunology, not allergy (they're part of the same specialty). They can be hard to find. The Immune Deficiency Foundation has a doctor list. I can't post a link but you can find their website by searching. This is a list...
  3. R

    For those with CFS who have done 23andMe testing...

    Those are actually the normal alleles, not variants. It's not that unusual for third party analysis to be wrong (Livewello is the worst). Promethease is the only one I have found to be consistently accurate. Jan
  4. R

    For those with CFS who have done 23andMe testing...

    ALLELIC VARIANTS .0001 SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-POSITIVE, NK CELL-POSITIVE IL7R, THR66ILE [dbSNP:rs1494558] [ClinVar] In a patient with T-, B+, NK+ SCID (608971), Puel et al. (1998) identified 2 homozygous mutations in the IL7R gene: a...
  5. R

    For those with CFS who have done 23andMe testing...

    Both of those are listed as allelic variants associated with SCID on the OMIM page for IL-7R. Even if you have the risk alleles it is important to confirm with immune function testing like the panels I mentioned above. A researcher I spoke with said they're seeing more and more adults...
  6. R

    For those with CFS who have done 23andMe testing...

    This is the SNP on IL-21R where I am homozygous for the variant: rs12934152 C:C (normal T, variant C) Having a variant on a SNP does not mean it will affect the production of the protein or enzyme. If you have one variant like CT it is called heterozygous, if you have two it is homozygous...
  7. R

    For those with CFS who have done 23andMe testing...

    Mattias, We have run many other tests since then which confimed the immune deficiency including a B cell panel which contains naive and memory b cells. That raised the question of another type of gene mutation which is the Interleukin 21 receptor, and I also confirmed mutations in that gene...
  8. R

    For those with CFS who have done 23andMe testing...

    We have known for years that I have some sort of immune deficiency that makes me very susceptible to viruses and chronic EBV, CMV, Parvo and other infections. My immunologist was not sure about the exact cause, but I have been working my way through my 23andMe raw data and looking for...
  9. R

    Immune activation and depression

    I have very high natural interferon levels, probably because my immune system is always fighting viruses that are trying to reactivate. For me those are Epstein-Barr, Cytomegalovirus and Parvo. I also have fairly high titers to mycoplasma. I have a genetic condition that causes me to lose...
  10. R

    The Medical Reason for Pesticide Sensitivity

    Ian, I have several CYP2D6 SNPs and two CYP2E1 SNPs. But I think what causes the low vitamin D are the Vitamin D Receptor Bas and Taq mutations. I mainly started taking Riboflavin-5-Phosphate because I am very intolerant of NADH supplements. I wondered if I didn't convert riboflavin to the...
  11. R

    Adrenal Fatigue (Cortisol Deficiency) And Insomnia-congrats . .

    They do carry several supplements that help with adrenal function. For instance Adrenal Energy has things like B-5, DHEA, tyrosine, etc. They can't sell prednisone or hydrocortisone because they aren't a registered pharmacy. I really like royal jelly for adrenal support. I don't see that...
  12. R

    The Medical Reason for Pesticide Sensitivity

    Ian, it did take some time to study the various SNPs and determine if they had any clinical significance. Fortunately there were many articles on PubMed that referred to specific mutations and the impact (as you mentioned, sometimes there is no impact). As for the vitamin D and methylation...
  13. R

    "Elephant in the Room"! CFS and Addison's Disease (Cortisol Deficiency)

    I think this is often overlooked in treating chronic fatigue. Years ago CFS doctors were telling patients to increase their sodium which helps compesate for adrenal insufficiency. I do think before starting therapy it's a good idea to get a cortisol profile with samples taken at different...
  14. R

    The Medical Reason for Pesticide Sensitivity

    I recently got DNA testing done through 23andMe.com ($99). There is a plugin that you can use to look at your detoxification profile. It shows mutations called single nucleotide polymorphisms or SNPs that are occurring in the pathways that detoxify things like medications and pesticides. If...
  15. R

    Neighbor Spraying Chemicals and Smoking Making Me Worse

    I live in a condo complex and have the same issues. The worst for me is the scented detergents and fabric softeners. I run around closing windows and sometimes even have to leave for a while. I had to seal off my bathroom vent because many fumes were coming in from shared vents. I put weather...
  16. R

    d ribose, coq10, magnesium

    My cardiologist recommended the above book last week. He says after reading it he now recommends L-Carnitine, Ubiquinol (form of CoQ10), D-Ribose and Magnesium for his patients. I buy all mine online, but you can find them at any good-sized health food store. I use Acetyl-L-Carnitine because...
  17. R

    how do people with cfs m.e get better?

    If you can find a good homeopath you might get some relief from the symptoms. When I was at my worst about 20 years ago homeopathics saved my life. I studied homeopathy for several years so that I could find my own remedies based on current symptoms and it has helped tremendously. Over the...
  18. R

    do foods give you energy?

    Suzi, There are some genetic conditions that can keep you from using fats in your diet for fuel, and others that cause low cellular phosphorus levels so that you don't have enough ATP for energy. If you can find a mitochondrial disease specialist in your area you might get some answers. Here...
  19. R

    Rebreather Mask, Hyperventilation and Alkalosis

    Paul, I have chronic metabolic lactic acidosis (respiratory alkalosis) from a genetic condition and have found that these masks really help me: http://icanbreathe.com/store/honeycomb1.html They are light enough that I don't feel like I'm suffocating if I'm moving around, and I don't react to...
  20. R

    Genetic Testing - Update

    I received 23andMe results a few weeks ago, and over the weekend I plugged the raw data into a program that correlates some of the results with Amy Yasko's methylation testing and a detox analysis (GeneticGenie.org). This has really solved some mysteries for me...I had five different mutations...
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