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[Effect of curcumin on IL-17-induced nitric oxide production and expression of iNOS in human keratinocytes].
[Article in Chinese]
Yang ZS1, Peng ZH, Li XL, Song JW, Ren JW.
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"To investigate the effect of curcumin on IL-17-induced NO production, mRNA and protein expression of iNOS in human keratinocyte cell lines(HaCaT cells)."

"HaCaT cells were stimulated with IL-17 and incubated with three doses of curcumin for 24h in vitro. After collections of supernatant, total RNA and protein, NO levels in supernatant were detected and fluorescence quantitative PCR and Western blot were performed to determine the effect of curcumin on NO levels and iNOS."

"IL-17 increased NO levels, and expression of iNOS in HaCaT cells(P<0.01). Curcumin decreased IL-17 induced NO production and the iNOS expression at mRNA (P<0.01) and protein (P<0.01) levels significantly."

"Curcumin down-regulates IL-17-induced NO secretions and iNOS expression in HaCaT cells, thus provides a theoretical basis for the treatment of inflammatory diseases of skin related to keratinocytes."

-See more here:http://www.ncbi.nlm.nih.gov/pubmed/21906467
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More Positive Results: Low-Dose Naltrexone for Fibromyalgia
Up-and-Coming Treatment Shows Promise

"Stanford University researchers have again found that low-dose naltrexone (LDN) is a beneficial treatment for fibromyalgia."

"The new study, just published in Arthritis and Rheumatism, aimed to confirm and expand Stanford's earlier research on LDN. It's small and still considered preliminary, but continued positive outcomes of this kind are necessary for moving up to larger studies."

"In this study, participants taking LDN had:"

  • 28% reduction in pain
  • Improved satisfaction with life
  • Improved mood
  • NO improvement in fatigue or sleep
  • NO serious side effects

"Especially good news for people with fibromyalgia, who are often especially prone to side effects, is that LDN was tolerated just as well as a placebo."

"LDN is an inexpensive, widely available medication with a long record of being safe and well tolerated. If positive results continue through larger trials, it could become an excellent option for people with fibromyalgia. As is, some doctors are willing to prescribe it, but many are likely to be reluctant until we have more data."

See more here: http://chronicfatigue.about.com/b/2013/02/08/more-positive-results-low-dose-naltrexone-for-fibromyalgia.htm