I worked in a team looking at high dose ascorbate (HDA) many years ago. I have always been against using it for ME/CFS.
1. their is little evidence that it is an antiviral
2. people with MECFS have ATP synthesis dysfunction due mainly to mitochondrial dysfunction (I have spoken about this on previous posts). some of these people have a glucose-6-phosphate dehydrogenase deficiency (not necessarily genetic) so this should be pre-tested in all cases for HDA.
3. because ascorbate is a chelating agent, some individuals may experience symptoms of low serum calcium. (typically tremor, vertigo and nausea)
4. it is contraindicated in renal insufficiency and could possibly cause kidney stones. (although the evidence for this is weak)
5. sclerosing of peripheral veins occurs from intravenous push but not from drip yet many doctors are giving the HDA by intravenous push. Also PWME can have low blood volume so this exacerbates this reaction due to high osmolality of the HDA. (Would make the ME patient feel sick for several days, possibly weeks).
6. HDA can increase the oxidation of lipid peroxides. These are known to be a problem in people with ME and with FM. This results in the increased level of ROS which the mitochondria cannot deal with properly in PWME. This will make the PWME feel quite sick and weak and have a stronger reaction to toxin or xenobiotic exposure and therefore use up pools of glutathione.
[This Message was Edited on 01/16/2013]