Does anyone have experience of paradoxical reactions to anti depressants and anti anxiety meds?. I was on duloxetine for years with no problems before getting Ill. I have tried many meds and supplements since but always get an adverse reaction. At the moment I'm coming off Trazadone and I'm on Lithium carbonate( 200mg). I can't stop crying and feel awful, but I think that's withdrawal. I don't know whether to continue the lithium or not.